University of Groningen
Genetic defects in myeloid malignancies and preleukemic conditions Berger, Gerbrig
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2019
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Berger, G. (2019). Genetic defects in myeloid malignancies and preleukemic conditions. Rijksuniversiteit Groningen.
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Genetic defects in myeloid malignancies
and preleukemic conditions
The studies described in this thesis were performed at the Department of Experimental Hematology of the University Medical Center Groningen, The Netherlands.
Printing of this thesis was financially supported by University of Groningen, UMCG Graduate School of Medical Sciences, Stichting tot bevordering der haematologie Groningen, MPN stichting and Onderzoeksfonds Hematon.
ISBN: 9789403416298
Cover and lay-out design: G. Berger
Printing: Ipskamp Drukkers BV, Enschede Copyright © 2019, Gerbrig Berger
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means without permission of the author
Genetic defects in myeloid malignancies and preleukemic conditions
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus Prof. Dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 22 mei 2019 om 16.15
door
Gerbrig Berger geboren op 5 juni 1989
te Heerenveen
Promotor
Prof. Dr. E. Vellenga Copromotor
Dr. H. Schepers
Beoordelingscommissie Prof. Dr. G. de Haan
Prof. Dr. M.H.G.P. Raaijmakers
Prof. Dr. M.A.T.M. van Vugt
Foar myn suskes
Paranimfen
Katharina Mattes
Aida Rodríguez-López
Contents
Chapter 1 General introduction p.9
Chapter 2 Early detection and evolution of preleukemic clones in therapy-related myeloid neoplasms following autologous SCT (Blood, 2018)
p.27
Chapter 3 Ringsideroblasts in acute myeloid leukemia are associated with adverse risk and result from an aberrant heme- metabolism gene program
(Submitted)
p.65
Chapter 4 Overexpression of TP53 is associated with poor survival, but not with reduced response to hypomethylating agents in older patients with acute myeloid leukaemia
(British Journal of Haematology, 2016)
p.95
Chapter 5 Hereditary hematological malignancies presenting in adulthood
(Leukemia, 2017 and British Journal of Haematology, 2018)
p.103
Chapter 6 CITED2-mediated human hematopoietic stem cell maintenance is critical for acute myeloid leukemia (Leukemia, 2015)
p.115
Chapter 7 CITED2 affects leukemic cell survival by interfering with p53 activation
(Cell, Death and Disease, 2018)
p.143
Chapter 8 Summary, discussion and future perspectives p.163
Appendices
Nederlandse samenvatting Dankwoord
Over de auteur Publicaties
p.181
