University of Groningen
Responses of Staphylococcus aureus to mechanical and chemical stresses
Carniello, Vera
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Publication date: 2018
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Carniello, V. (2018). Responses of Staphylococcus aureus to mechanical and chemical stresses. Rijksuniversiteit Groningen.
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Responses of Staphylococcus aureus
to mechanical and chemical stresses
Responses of Staphylococcus aureus to mechanical and chemical stresses
University Medical Center Groningen, University of Groningen Groningen, The Netherlands
Copyright © 2018 by Vera Carniello
Cover: 3D illustration of Staphylococcus aureus adhering to a surface, istockfotos Dr_Microbe
Layout by kahle-design
Printed by ProefschriftMaken || www.proefschriftmaken.nl ISBN (printed version): 978-94-034-1121-7
Responses of Staphylococcus aureus
to mechanical and chemical stresses
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 26 november 2018 om 14:30 uur
door
Vera Carniello
geboren op 9 februari 1989 te Pordenone, Italië
Promotores: Prof. dr. H. C. van der Mei
Prof. dr. ir. H.J. Busscher Copromotor: Dr. B. W. Peterson Beoordelingscommissie: Prof. dr. J. Liu Prof. dr. B. Poolman Prof. dr. E. M. J. Verpoorte
Paranimfen:
Ana Maria Almonacid Suarez Magdalena Wójcik
TABLE OF CONTENTS
Chapter 1.1
The transition from bacterial adhesion to the production 9 of EPS and biofilm formation
Chapter 1.2
Aim of this thesis 33
Chapter 2
Adhesion force sensing and activation of a membrane-bound 39 sensor to activate nisin efflux pumps in Staphylococcus
aureus under mechanical and chemical stresses
Chapter 3
Surface enhanced fluorescence and nanoscopic cell wall 57 deformation in adhering Staphylococcus aureus upon
exposure to cell wall active and non-active antibiotics
Chapter 4
Role of adhesion forces in mechanosensitive channel 83 gating in Staphylococcus aureus adhering to surfaces
Chapter 5
General discussion: Initial bacterial adhesion and 107 surface-programmed biofilm growth
