University of Groningen
Bacterial natural products Ceniceros, Ana
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Publication date: 2017
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Ceniceros, A. (2017). Bacterial natural products: Prediction, regulation and characterization of biosynthetic gene clusters in Actinobacteria. University of Groningen.
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Bacterial natural products
Prediction, regulation and characterization
of biosynthetic gene clusters in
Actinobacteria
Ana Ceniceros
Microbial Physiology
University of Groningen
The work described in this thesis was carried out in the Microbial Physiology group of the Groningen Biomolecular Sciences and Biotechnology Institute (GBB) of the University of Groningen, The Netherlands. The author gratefully acknowledges the financial support of University of Groningen and the GBB for printing this thesis
This research was supported by the Dutch Technology Foundation STW, which is part of the Netherlands Organization for Scientific Research (NWO), and which is partly funded by the Ministry of Economic Affairs, and by the University of Groningen.
Cover design: Javier Alonso-Olalla Printed by: Ipskamp Drukkers, Enschede ISBN: 978-90-367-9506-7
Bacterial natural products
Prediction, regulation and characterization of biosynthetic gene clusters in Actinobacteria
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Friday 17 February 2017 at 11.00 hours
by
Ana Ceniceros born on 23 March 1986
Supervisor
Prof. L. Dijkhuizen
Co-supervisor
Dr. J.M. Petrusma
Assessment Committee
Prof. O.P. Kuipers Prof. A.J.M. Driessen Prof. H.A.B. Wosten
Contents
Chapter 1: General introduction ... 1
Natural products and their physiological roles... 2
Human uses of natural products ... 10
Potential of bacterial natural product synthesis ... 12
Scope of this thesis ... 23
Chapter 2: Characterization of the Streptomyces clavuligerus indigoidine synthetase and its associated tautomerase ... 35
Chapter 3: Identification and characterization of the tunicamycin-like antibiotics (MM 19290) of Streptomyces clavuligerus ... 65
Chapter 4: Genome-based exploration of the specialized metabolic capacities of the genus Rhodococcus ... 97
Chapter 5: Molecular characterization of a Rhodococcus jostii RHA1 γ-butyrolactone-like signalling molecule and its main biosynthesis gene gblA ... 141
Chapter 6.1: Summary and concluding remarks ... 171
Hoofdstuk 6.2: Samenvatting en conclusies ... 181
Capítulo 6.3: Resumen y conclusiones ... 193
