University of Groningen
On the Total Synthesis of Archaeal and Mycobacterial Natural Products
Holzheimer, Mira
DOI:
10.33612/diss.150711132
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Publication date: 2021
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Citation for published version (APA):
Holzheimer, M. (2021). On the Total Synthesis of Archaeal and Mycobacterial Natural Products. University of Groningen. https://doi.org/10.33612/diss.150711132
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Stellingen
behorende bij het proefschrift
On the Total Synthesis of Archaeal and Mycobacterial Natural Products
door
Mira Holzheimer
1. The main objective of universities should solely be education and research, not publicity, profit and prestige.
2. A detailed description of experimental procedures and analytical data of all synthesized compounds is essential for every organic synthesis publication.
Angew. Chem. Int. Ed. 2003, 42, 2419-2421, this thesis Chapter 3
3. Total Synthesis is the golden standard for confirmation of the chemical structure and stereochemistry of complex natural products.
This thesis Chapters 4, 6 and 7.
4. One of the most powerful analysis techniques for organic synthesis is Thin Layer Chromatography combined with a careful selection of staining agents.
5. In the past decade, photopharmacology of azobenzene switches has evolved into a promising research field. To further demonstrate its potential for future medical applications, studies need to include an assessment of pharmacokinetic properties, such as (metabolic) stability, toxicology and/or off-target engagement of both isomers.
J. Med. Chem. 2020, 63, 20, 11436–11447
6. Column chromatography by hand is an essential skill for every organic chemist to master. 7. It is of paramount importance to review the literature on the stability of the reagents used in
chemical reactions.
ChemRxiv, 2020. DOI: 10.26434/chemrxiv.12818234.v1
8. Comparison of the optical rotations of natural and synthetic chiral molecules is not enough to assess absolute stereochemistry. Instead, vibrational circular dichroism (VCD) is a more accurate and conclusive analytical method.
Chem. Sci., 2018, 9, 415-424
9. 13C NMR integration of appropriately selected signals for the determination of diastereomeric
ratios is an accurate yet underestimated analytical tool. Consequently, chemistry education will benefit from treating this topic in a more nuanced fashion.
Org. Lett. 2014, 16, 6, 1566–1569 10. Honesty is key to good science.
