University of Groningen
Exploiting the Biomolecular Corona of Nanocarriers for Targeted drug Delivery to Endothelial Cells
Aliyandi, Aldy
DOI:
10.33612/diss.133166778
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Aliyandi, A. (2020). Exploiting the Biomolecular Corona of Nanocarriers for Targeted drug Delivery to Endothelial Cells. University of Groningen. https://doi.org/10.33612/diss.133166778
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Propositions
Associated with the PhD Thesis
Exploiting the Biomolecular Corona of Nanocarriers for Targeted Drug Delivery
to Endothelial Cells
By Aldy Aliyandi
1. In order to reach their target, nano-sized carriers and drugs need to overcome a series of barriers at organ, tissue, and cellular levels. Among these, endothelial cells constitute one of the very first barriers that nanomedicine need to overcome in order to reach the target organ following administration into the bloodstream. (This thesis)
2. Endothelial cells from different organs have very different nanoparticle uptake efficiency, thus endothelial cell heterogeneity affects nanoparticle uptake. (This thesis)
3. The biomolecular corona that adsorbs onto nanoparticles in biological fluids can confer a new biological identity to the nanoparticles and affect their subsequent interactions with cells. (This thesis)
4. The biomolecular corona can be exploited as a tool to discover potential ligands as well as receptors involved in nanoparticle uptake in specific cell types to be used for novel targeting strategies. (This thesis)
5. Nanoparticle uptake efficiency and uptake kinetics are strongly determined by the cell surface receptors to which the nanoparticles bind. (This thesis)
6. With clinicians, scientists, regulatory bodies, and the pharmaceutical industry working more closely together, they are likely to realize the full potential of nanomedicine and further revolutionize the healthcare system for the treatment of complex, rare, and currently incurable diseases. (Martins et al., Drug Delivery and Translational Research 2020)
7. There is no such thing as a failed experiment, only experiments with unexpected outcomes. (R. Buckminster Fuller)
8. Once we accept our limits, we go beyond them. (Albert Einstein)
9. To be kind is more important than to be right. Many times what people need is not a brilliant mind that speaks but a special heart that listens. (F. Scott Fitzgerald)
