University of Groningen
Evolution of karyotype landscapes in cancer Bakker, Bjorn
DOI:
10.33612/diss.166886747
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Publication date: 2021
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Bakker, B. (2021). Evolution of karyotype landscapes in cancer. University of Groningen. https://doi.org/10.33612/diss.166886747
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1. Mouse models genetically engineered to provoke chromosomal instability (CIN) provide a valuable means of studying the in vivo consequences of CIN and aneuploidy (Chapter 1).
2. Single-cell whole genome sequencing is a crucial tool to
understand the roles of CIN and karyotype heterogeneity in cancer biology (Chapter 2).
3. CIN is an enabler, not an initiator of tumorigenesis (Chapters 1, 3 & 4).
4. Cancer cells evolve towards a defined tissue-specific karyotype (Chapters 3, 4 & 6).
5. Tumours undergoing CIN rapidly evolve towards a state of karyotypic equilibrium, where new karyotypes are continuously generated and selected for optimal fitness (Chapters 5 & 6). 6. Understanding the routes of tumour evolution, how karyotypes affect the transcriptional and mutational landscapes, will greatly benefit optimization of diagnosis, prognosis, and treatment strategies (Chapters 7 & 8, e.g. Jamal-Hanjani et al., 2017).
7. Bioinformatics is a powerful tool to help understand the
complexities of biology, but it can at times venture into abstract and unrealistic territories. One should therefore always be aware that the real world exists.
8. Nothing in biology makes sense except in the light of evolution. Theodosius Dobzhansky
9. Otium sine litteris mors est et hominis vivi sepultura. Lucius Annaeus Seneca
10. Je moet gewoon niet te diep nadenken, en dan klopt alles. Herman Finkers
11. Do, or do not. There is no try. Yoda
