(2) The Role of Quiescent and Cycling Stem Cells in the Development of Skin Cancer
Hele tekst
(2) The Role of Quiescent and Cycling Stem Cells in the Development of Skin Cancer. UITNODIGING. The Role of Quiescent and Cycling Stem Cells in the Development of Skin Cancer. Voor het bijwonen van de openbare verdediging van het proefschrift. The Role of Quiescent and Cycling Stem Cells in the Development of Skin Cancer door Gerline van de Glind Op woensdag 18 april 2018 om 16.15u in de Senaatskamer van het Academiegebouw, Rapenburg 73 te Leiden. Na afloop bent u van harte welkom op de receptie die aansluitend zal plaatsvinden in de receptieruimte van het Academiegebouw. Parkeren in de omgeving van het Academiegebouw is vaak moeilijk en tijdrovend.. Gerline van de Glind Beukstraat 53 3581 XE Utrecht Paranimfen Ilse Haisma Arianne Oberendorf. Gerline van de Glind. phdvandeglind@gmail.com. Gerline van de Glind.
(3)
(4) . . . .
(5) .
(6) .
(7) .
(8) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15374-vdGlind_BNW.indd 1. . 12-03-18 13:01. 15374-vdGlind_BNW.indd 1. 12-03-18 13:01.
(9) "!%#$(#$#$& $#" $##) &"#$() $"# ("$©++&)$"$)3128 "$# "#"&+ "$ $# %$ ( " "% " $"#$$ ( ""((#'$%$ "" "##$%$"+ *978,95,6399,877,4 (,%$&" $*++& &"(,%$*+&" )
(10) " "$++ "$(*
(11) " "$++ #"#" "$'#%($%$" $(- 3121,5823.+ #% "$" "$$#$##'#( "&($%$" $(+ . 15374-vdGlind_BNW.indd 2.
(12)
(13) '%)%%")" %)"#'#%"")%&'' ", #$+)"'#%
(14) "(&,$%#-!%-- - -
(15) -'# %, )# "&& (')"'# )##%%#!#'& "!%#$(#$#$& $#" ')%"#$*#"&15$% 2015 $##) &"#$() $"# #14-13((% ("$©++&)$"$)3128 "$# "#"&+ "$ $# %$ ##% ( " "% " $"#$$ ( ""((#'$%$ "" "##$%$"+ *978,95,6399,877,4 #%"'!%&##%'"1654 (,%$&" $*++& &"(,%$*+&" )
(16) " "$++ "$(*
(17) " "$++ #"#" "$'#%($%$" $(- 3121,5823.+ #% "$" "$$#$##'#( "&($%$" $(+ . 12-03-18 13:01. 15374-vdGlind_BNW.indd 2. 12-03-18 13:01.
(18)
(19)
(20) '%)%%")" %)"#'#%"")%&'' ", #$+)"'#%
(21) "(&,$%#-!%-- - -
(22) -'# %, )# "&& (')"'# )##%%#!#'& "!%#$(#$#$& $#" ')%"#$*#"&15$% 2015 $##) &"#$() $"# #14-13((% ("$©++&)$"$)3128 "$# "#"&+ "$ $# %$ ##% ( " "% " $"#$$ ( ""((#'$%$ "" "##$%$"+ *978,95,6399,877,4 #%"'!%&##%'"1654 (,%$&" $*++& &"(,%$*+&" )
(23) " "$++ "$(*
(24) " "$++ #"#" "$'#%($%$" $(- 3121,5823.+ #% "$" "$$#$##'#( "&($%$" $(+ . 15374-vdGlind_BNW.indd 3. 12-03-18 13:01. . .
(25)
(26) . . '%)%%")" %)"#'#%"")%&'' ", #$+)"'#%
(27) "(&,$%#-!%-- - -
(28) -'# %, )# "&& (')"'# )##%%#!#'& ')%"#$*#"&15$% 2015 #14-13((% ##%. #%"'!%&##%'"1654. . . . 15374-vdGlind_BNW.indd 3. 12-03-18 13:01.
(29) . . .
(30) . . .
(31) !" $"! 6 " 0 " #" 8
(32) " 1 *#"" !' # 12 42*#""! !"! !!!%!##! !" " " # !)
(33)
(34)
(35)
(36)
(37) " 2 """# *""!" #! 36 * "! !!#!! !
(38)
(39)
(40) !#!#" * ""# !* !! " 3 49!"!" '#! !# 64 !&#!! !!(" ! !#!"# ! " 4 59!"!" '#! !# 0/0 !&#!! !!(" ! !#!"# ! " 5 *!'!! 59!"!""020 5! " 6
(41) # ' !#!! 046 " 7 !!$""+#"
(42) # ', 056.
(43)
(44)
(45)
(46)
(47)
(48)
(49)
(50)
(51) . . . . . . . . . . . . . . . . . . . . . . 15374-vdGlind_BNW.indd 4. . . !"#"! # ##". . . . . 062. . . . . 064. . . 12-03-18 13:01. 15374-vdGlind_BNW.indd 4. 12-03-18 13:01.
(52) . . . . .
(53) !" $"! 6 " 0 " #" 8
(54) " 1 *#"" !' # 12 42*#""! !"! !!!%!##! !" " " # !)
(55)
(56)
(57)
(58)
(59) " 2 """# *""!" #! 36 * "! !!#!! !
(60)
(61)
(62) !#!#" * ""# !* !! " 3 49!"!" '#! !# 64 !&#!! !!(" ! !#!"# ! " 4 59!"!" '#! !# 0/0 !&#!! !!(" ! !#!"# ! " 5 *!'!! 59!"!""020 5! " 6
(63) # ' !#!! 046 " 7 !!$""+#"
(64) # ', 056. . . . . . . . !"#"! # ##". . . . . 062. . . . . 064. " 0 " 1 " 2. " 3 " 4 " 5 " 6 " 7. . . . . . . !" $"!. . . . . . 6. " #". . . . . . 8. *#"" !' # 42*#""! !"! !!!%!##! !" " " # !). 12. """# *""!" #! * "! !!#!! ! !#!#" * ""# !* !! 49!"!" '#! !# !&#!! !!(" ! !#!"# !. 36. 64. 59!"!" '#! !# 0/0 !&#!! !!(" ! !#!"# ! *!'!! 59!"!""020 5!
(65) # ' !#!! . . !!$""+#"
(66) # ',. . !"#"! # ##". . 046. . 056. . . . . 062. . . . . 064. . . 15374-vdGlind_BNW.indd 5. 12-03-18 13:01. . 15374-vdGlind_BNW.indd 5. 12-03-18 13:01.
(67) . . . of abbreviations List +%) !
(68) " " . A2?%$)$%'$*) >2"#$2D2).!'/$! )# ')$(( )*! ##!#)"%')*' (!!!'#$" '$"$$-.*'# $+#('*"!*"# $"%!"#)'. $###)'+!( $#$!!('(###"'$($%. .!$*)#%.'"#"' 2')##(!!!( #'()"!!( ?80A2"#$2=2%#.!#$! ").!#/672#)'# $-.'$#*! ).!#"#))'2) ##'#!*$'(#) '$)# !(($+'.')( '$!!!. . #)'$!!*!'%'"( ( ')#< (' ')#<; () ')#<? * ')#@
(69) !*
(70) *#2''%)$#)##2 %'$)#$*%!'%)$'@
(71) !+
(72) *#2''%)$#)##2 %'$)#$*%!'%)$'A
(73)
(74) $##$#2$##
(75)
(76) $$*#)%'"!!$#((
(77)
(78) $$!#
(79)
(80) $(($)'$/.$().
(81)
(82) $)$
(83) "
(84) !2')##!!( #"!"1'.)"!$( ((#' % ).!)$#(%"!)# *'+#!.(( ## $)(##) $#2$#( $'"!$)('*" $'"! *"#'*" . . 15374-vdGlind_BNW.indd 6. $)<#)'!!*!'$"# $ +'#) $(%)*'(!# $!."'(#')$# *#)))+'!2)" " *(#)()"!!( #)').#*"' $#*! %" *#)))+%(&*## ! $($"! 2(%$##( &*"$*(!!'#$" )#'''$'$)"# $*(!# ""!!#*!$!'( $*$,# " *"$'2#))#!!( '"" #$ +!*( <=22)'#$.!2%$'$!2<>2 )) '#('%)$#()')() !)'+$!)')$# % !)'+$!)')$# 4><@3?;;#"5 % !)'+$!)')$# 4=C;2><@#"5 % !)'+$!)')$# 4<;;3=C;#"5 !).%. . B . 12-03-18 13:01. 15374-vdGlind_BNW.indd 6. 12-03-18 13:01.
(85) of abbreviations List +%) !
(86) " " . A2?%$)$%'$*) >2"#$2D2).!'/$! )# ')$(( )*! ##!#)"%')*' (!!!'#$" '$"$$-.*'# $+#('*"!*"# $"%!"#)'. $###)'+!( $#$!!('(###"'$($%. .!$*)#%.'"#"' 2')##(!!!( #'()"!!( ?80A2"#$2=2%#.!#$! ").!#/672#)'# $-.'$#*! ).!#"#))'2) ##'#!*$'(#) '$)# !(($+'.')( '$!!!. . #)'$!!*!'%'"( ( ')#< (' ')#<; () ')#<? * ')#@
(87) !*
(88) *#2''%)$#)##2 %'$)#$*%!'%)$'@
(89) !+
(90) *#2''%)$#)##2 %'$)#$*%!'%)$'A
(91)
(92) $##$#2$##
(93)
(94) $$*#)%'"!!$#((
(95)
(96) $$!#
(97)
(98) $(($)'$/.$().
(99)
(100) $)$
(101) "
(102) !2')##!!( #"!"1'.)"!$( ((#' % ).!)$#(%"!)# *'+#!.(( ## $)(##) $#2$#( $'"!$)('*" $'"! *"#'*" . $)<#)'!!*!'$"# $ +'#) $(%)*'(!# $!."'(#')$# *#)))+'!2)" " *(#)()"!!( #)').#*"' $#*! %" *#)))+%(&*## ! $($"! 2(%$##( &*"$*(!!'#$" )#'''$'$)"# $*(!# ""!!#*!$!'( $*$,# " *"$'2#))#!!( '"" #$ +!*( <=22)'#$.!2%$'$!2<>2 )) '#('%)$#()')() !)'+$!)')$# % !)'+$!)')$# 4><@3?;;#"5 % !)'+$!)')$# 4=C;2><@#"5 % !)'+$!)')$# 4<;;3=C;#"5 !).%. List of abbreviations +%) !
(103) " " . A2?%$)$%'$*) >2"#$2D2).!'/$! )# ')$(( )*! ##!#)"%')*' (!!!'#$" '$"$$-.*'# $+#('*"!*"# $"%!"#)'. $###)'+!( $#$!!('(###"'$($%. .!$*)#%.'"#"' 2')##(!!!( #'()"!!( ?80A2"#$2=2%#.!#$! ").!#/672#)'# $-.'$#*! ).!#"#))'2) ##'#!*$'(#) '$)# !(($+'.')( '$!!!. . #)'$!!*!'%'"( ( ')#< (' ')#<; () ')#<? * ')#@
(104) !*
(105) *#2''%)$#)##2 %'$)#$*%!'%)$'@
(106) !+
(107) *#2''%)$#)##2 %'$)#$*%!'%)$'A
(108)
(109) $##$#2$##
(110)
(111) $$*#)%'"!!$#((
(112)
(113) $$!#
(114)
(115) $(($)'$/.$().
(116)
(117) $)$
(118) "
(119) !2')##!!( #"!"1'.)"!$( ((#' % ).!)$#(%"!)# *'+#!.(( ## $)(##) $#2$#( $'"!$)('*" $'"! *"#'*" . . B . 15374-vdGlind_BNW.indd 7. 12-03-18 13:01. $)<#)'!!*!'$"# $ +'#) $(%)*'(!# $!."'(#')$# *#)))+'!2)" " *(#)()"!!( #)').#*"' $#*! %" *#)))+%(&*## ! $($"! 2(%$##( &*"$*(!!'#$" )#'''$'$)"# $*(!# ""!!#*!$!'( $*$,# " *"$'2#))#!!( '"" #$ +!*( <=22)'#$.!2%$'$!2<>2 )) '#('%)$#()')() !)'+$!)')$# % !)'+$!)')$# 4><@3?;;#"5 % !)'+$!)')$# 4=C;2><@#"5 % !)'+$!)')$# 4<;;3=C;#"5 !).%. . B. 15374-vdGlind_BNW.indd 7. 12-03-18 13:01.
(120) . 15374-vdGlind_BNW.indd 8. . 12-03-18 13:01. 15374-vdGlind_BNW.indd 8. 12-03-18 13:01.
(121) C������. 1. C������. G������ I�����������. 1. G������ I�����������. . 15374-vdGlind_BNW.indd 9. 12-03-18 13:01. 15374-vdGlind_BNW.indd 9. 12-03-18 13:01.
(122) 1. 1. 1. . 1. $ #!
(123) ( !$!!$'(($ & "& ! & $( & $ , - ( "$'( $ $ # ,-( $ ( !$&!" $ ( !"$ !!$# ( & !$ !$&( $$ 100 ,#" - $( $ $ " $ !$, 1(1-($!4,4- 13,13-$(! " ! $$#$$"4 131,1-10,10-#($&$ $ $&$$ , 1(1-( & $ $ $!)" *( ! 5" , 20$ &12$$13+20$ - .1& 2/( '" "(
(124)
(125)
(126)
(127) . "$ % * . ' $ $'% % $ "% " #!
(128) ( " ' " $ % " %" /* !$!!$'(($ & " ! ' " "& ! & " $ " # " $( & $ , -0 ' $ /*1$ %$ ( "' $ #!$ ' $ % " ! " $' "$'( $ $ # ,-( $ ( !$&!" $ ( !"$ !!$# ( & !$ !$&( $$ 100 ,#" - $( $ $ " $ !$, 1(1-($!4,4- 13,13-$(! " ! $$#$$"4 131,1-10,10-#($&$ ' $ $&$$ , 1(1-( & $ $ .
(129)
(130) $!)" *( ! 5" , % 20$ &12$$13+20$ .1& 2/( % ! $ - ! ! ' () *& ' '" "( " ' $ " !% &
(131)
(132)
(133)
(134) +,%$ % ' , 1(1-( "" "( "$! % ( . , 1(1-( "" "( "$! % ( ! ,-&"" ) * ( % . ! ,-&"" ) * ( % . 10. 15374-vdGlind_BNW.indd 10.
(135) . 10. 12-03-18 13:01. 15374-vdGlind_BNW.indd 10. . . ... 12-03-18 13:01.
(136) 1.
(137) .
(138) . "$ % * . ' $ $'% % $ "% " #!
(139) ( " ' " $ % " %" /* !$!!$'(($ & " ! ' " "& ! & " $ " # " $( & $ , -0 ' $ /*1$ %$ ( "' $ #!$ ' $ % " ! " $'. 1. "$'( $ $ # ,-( $ ( !$&!" $ ( !"$ !!$# ( & !$ !$&( $$ 100 ,#" - $( $ $ " $ !$, 1(1-($!4,4- 13,13-$(! " ! $$#$$"4 131,1-10,10-#($&$ ' $ $&$$ , 1(1-( & $ $ .
(140)
(141) $!)" *( ! 5" , % 20$ &12$$13+20$ .1& 2/( % ! $ - ! ! ' () *& ' '" "( " ' $ " !% &
(142)
(143)
(144)
(145) +,%$ % ' , 1(1-( "" "( "$! % ( . "$ % * ' $ $'% % "% " " ' " $ % " %" /* " ! ' " " $ " # " ' $ /*1$ %$ 0 "' $ #!$ ' $ % " ! " $'. 1. . '. . .
(146)
(147) % % ! $ ! ! ' () *& ' " " ' $ !% & +,%$ % ' . ! ,-&"" ) * ( % 10. 15374-vdGlind_BNW.indd 11. . . ... . 12-03-18 13:01. 15374-vdGlind_BNW.indd 11. . ... 12-03-18 13:01.
(148) <. 1. <.
(149)
(150)
(151) . 1. &&&' !'&%!'&4%'!!&5 &6/'%"! ' !"!' &! " *' '%'' ', ! "% ', ! !"- %" ""+,(%!5%6-'&&&'&"*'!'%!( "!'&'%/ '!'"! " ' #& '' '& & %, ) ! % ! ! "% !' "% 0$(&!'1&''/&$(&!'&' &5&6*%"'!'&,%"' #% &'*!'%"&!!'(%"!"'%"7>8/( & #%") '" #"&')"% ' '"#"' &' ! #%"!'"% %% >? ! *% &""(! '" +#%&& &#,
(152) <@/ +#% !'& *' &') '"! " '& &&"*'''#%"!,"'
(153) <@E&!"'"!'%(''"' #% &! % ! ! ' "& 7?8/ )!',- & #%&&' (''% !( %& %& *' .'%<? "!'&',*%!""!%"&%)!'!'%"(%5 6#% &-(' &" &'#%&&'!'(%"!"%"&7>8/%&&'!&%'%&'" &' &-('" #'"%#'"!!"!&$(!',#% !!'%'!'"!" %&!"'/&' !&&%,!&'"%#'!!%'#%"!,/%"%-' *&'"(''''&&)%%,!'''%%'#%"!,"% #""" ,#%"%'!2'%!&' #,!&3''%,%")'#% '(%!")%7>8/
(154)
(155)
(156)
(157)
(158)
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vdGlind_BNW.indd 12.
(160)
(161)
(162)
(163) &&&' !'&%!'&4%'!!&5 &6/'%"!
(164)
(165) ' !"!' &! " *' '%'' ', ! "% ', ! !"- $"& $34"$ " $#%!)#! "$$" $$ ) #". %" ""+,(%!5%6-'&&&'&"*'!'%!( "!'&'%/ &# "$ '$ '&$# ' >:: ""# & $ $+ '!'"! " ' #& '' '& & %, ) ! % ! ! "% !' "% & 2 3=;?2>:: 4+ 2 3<B:2=;? 4 2 3;::2<B: 4. 0$(&!'1&''/&$(&!'&' &5&6*%"'!'&,%"' #$"$ #!" * )" #!"$ $# ""$ -2 !$)2 #% &'*!'%"&!!'(%"!"'%"7>8/( ""!"$. )"$ 2 #$ $2"$"$/##%".$ & #%") '" #"&')"% ' '"#"' &' ! #%"!'"% %% >? ! # $$ # "$ 3G ?F4 # " %( $ 2 " $ " % & $$ # *% &""(! '" +#%&& &#,
(166) <@/ +#% !'& *' &') '"! " '& !" $)"#! #37B:F4 "$"%$# "$ +#%##%%". &&"*'''#%"!,"'
(167) <@E&!"'"!'%(''"' #% &! # #"&# # !" $$& )" #$ "$ ) # " !"$ $ $ % ! ! ' "& 7?8/ )!',- & #%&&' (''% !( %& %& *' #$"$% "%. " "$ !$"$# $ $ #. "$ .'%<? "!'&',*%!""!%"&%)!'!'%"(%5 6#% &-(' '&$# "$ !$"$$ "$!$#,2!$"$#$" %$ &" &'#%&&'!'(%"!"%"&7>8/%&&'!&%'%&'" !"#$ $"#.%#2")!$"$#!#$$!"#5;:6+%$ &' &-('" #'"%#'"!!"!&$(!',#% !!'%'!'"!" 2!$"$# "#)+#$!"##%$"$%# %&!"'/&' !&&%,!&'"%#'!!%'#%"!,/%"%-' 5;;6. *&'"(''''&&)%%,!'''%%'#%"!,"% #""" ,#%"%'!2'%!&' #,!&3''%,%")'#% '(%!")%7>8/
(168) .
(169)
(170)
(171) # # "
(172)
(173)
(174)
(175) "$ &"" $#$ ) . $# "
(176)
(177) !)" ## #$" " !""$) ) # "$2'&$ "%%!',&' &)!!'''-!"!'%&''"'$(&!'&' &- "$ 324+ " "# $' $# ##- $" ) %$ !)" '),#%"%'/,##%'"')%')2*"%"%&&3!#'%!*/ " 3
(178) 4 " @2> ! $ !" %$ 3@2>
(179)
(180) 4 5;<+ ;=6.
(181) #+ " # @2>
(182)
(183) #+ %# &&*%!','+#%&&"!" %@! %A/&#%"'!&%(!4 #$ "$ $ ('$$#"!" $# # # %%#'"!'!!4#%"'!"(#%#'"%&-"*#%"'"',#%#'"%*&%&' 5;>+ ;?6. ""#E$ # %" * $ ! )"##. !'! &!& 7@8/ %@ &' & *% %&'!' ! '!'&'!/ %% ' / "!$ #% 0 2#$"%$&1 E## ) & "# $ #$%" &"*,"!'% !'%!''' %@ &!'%,#'&"'& !'&'! %$$ #- )$ # 34 $ $) 34 $ #$# $ !)"# $ !""!*%%#,,!&' &-//-',*%!"'' &!'%,#'&7A8/ & $"#$ #5;@+;A6.
(184) #&&"#$ %#$""#)#$"!$ '/*!'"!'"&"*'' %@E&*%&",!&' &!'(!"*% "#5;B6$%#%#" # ""$ #. ("'%"&-!"!&$(!','&&!"'!(' &%(# %"$" "+
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vdGlind_BNW.indd 12. . . ;=. 12-03-18 13:01.
(186) <. . .
(187)
(188)
(189)
(190) &&&' !'&%!'&4%'!!&5 &6/'%"!
(191)
(192) ' !"!' &! " *' '%'' ', ! "% ', ! !"- $"& $34"$ " $#%!)#! "$$" $$ ) #". %" ""+,(%!5%6-'&&&'&"*'!'%!( "!'&'%/ &# "$ '$ '&$# ' >:: ""# & $ $+ '!'"! " ' #& '' '& & %, ) ! % ! ! "% !' "% & 2 3=;?2>:: 4+ 2 3<B:2=;? 4 2 3;::2<B: 4. 0$(&!'1&''/&$(&!'&' &5&6*%"'!'&,%"' #$"$ #!" * )" #!"$ $# ""$ -2 !$)2 #% &'*!'%"&!!'(%"!"'%"7>8/( ""!"$. )"$ 2 #$ $2"$"$/##%".$ & #%") '" #"&')"% ' '"#"' &' ! #%"!'"% %% >? ! # $$ # "$ 3G ?F4 # " %( $ 2 " $ " % & $$ # *% &""(! '" +#%&& &#,
(193) <@/ +#% !'& *' &') '"! " '& !" $)"#! #37B:F4 "$"%$# "$ +#%##%%". &&"*'''#%"!,"'
(194) <@E&!"'"!'%(''"' #% &! # #"&# # !" $$& )" #$ "$ ) # " !"$ $ $ % ! ! ' "& 7?8/ )!',- & #%&&' (''% !( %& %& *' #$"$% "%. " "$ !$"$# $ $ #. "$ .'%<? "!'&',*%!""!%"&%)!'!'%"(%5 6#% &-(' '&$# "$ !$"$$ "$!$#,2!$"$#$" %$ &" &'#%&&'!'(%"!"%"&7>8/%&&'!&%'%&'" !"#$ $"#.%#2")!$"$#!#$$!"#5;:6+%$ &' &-('" #'"%#'"!!"!&$(!',#% !!'%'!'"!" 2!$"$# "#)+#$!"##%$"$%# %&!"'/&' !&&%,!&'"%#'!!%'#%"!,/%"%-' 5;;6. *&'"(''''&&)%%,!'''%%'#%"!,"% #""" ,#%"%'!2'%!&' #,!&3''%,%")'#% '(%!")%7>8/
(195) .
(196)
(197)
(198) # # "
(199)
(200)
(201)
(202) "$ &"" $#$ ) . $# "
(203)
(204) !)" ## #$" " !""$) ) # "$2'&$ "%%!',&' &)!!'''-!"!'%&''"'$(&!'&' &- "$ 324+ " "# $' $# ##- $" ) %$ !)" '),#%"%'/,##%'"')%')2*"%"%&&3!#'%!*/ " 3
(205) 4 " @2> ! $ !" %$ 3@2>
(206)
(207) 4 5;<+ ;=6.
(208) #+ " # @2>
(209)
(210) #+ %# &&*%!','+#%&&"!" %@! %A/&#%"'!&%(!4 #$ "$ $ ('$$#"!" $# # # %%#'"!'!!4#%"'!"(#%#'"%&-"*#%"'"',#%#'"%*&%&' 5;>+ ;?6. ""#E$ # %" * $ ! )"##. !'! &!& 7@8/ %@ &' & *% %&'!' ! '!'&'!/ %% ' / "!$ #% 0 2#$"%$&1 E## ) & "# $ #$%" &"*,"!'% !'%!''' %@ &!'%,#'&"'& !'&'! %$$ #- )$ # 34 $ $) 34 $ #$# $ !)"# $ !""!*%%#,,!&' &-//-',*%!"'' &!'%,#'&7A8/ & $"#$ #5;@+;A6.
(211) #&&"#$ %#$""#)#$"!$ '/*!'"!'"&"*'' %@E&*%&",!&' &!'(!"*% "#5;B6$%#%#" # ""$ #. ("'%"&-!"!&$(!','&&!"'!(' &%(# %"$" "+
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vdGlind_BNW.indd 13. . . 1.
(213) . 1.
(214)
(215) $"& $34"$ " $#%!)#! "$$" $$ ) #". &# "$ '$ '&$# ' >:: ""# & $ $+ & 2 3=;?2>:: 4+ 2 3<B:2=;? 4 2 3;::2<B: 4. #$"$ #!" * )" #!"$ $# ""$ -2 !$)2 ""!"$. )"$ 2 #$ $2"$"$/##%".$ # $$ # "$ 3G ?F4 # " %( $ 2 " $ " % & $$ # !" $)"#! #37B:F4 "$"%$# "$ +#%##%%". # #"&# # !" $$& )" #$ "$ ) # " !"$ $ $ #$"$% "%. " "$ !$"$# $ $ #. "$ '&$# "$ !$"$$ "$!$#,2!$"$#$" %$ !"#$ $"#.%#2")!$"$#!#$$!"#5;:6+%$ 2!$"$# "#)+#$!"##%$"$%# 5;;6.
(216) .
(217)
(218)
(219) "$ &"" $#$ # # " ) . $# " !)" ## #$" " !""$) ) # "$2'&$ "$ 324+ " "# $' $# ##- $" ) %$ !)" " 3
(220) 4 " @2> ! $ !" %$ 3@2>
(221)
(222) 4 5;<+ ;=6.
(223) #+ " # @2>
(224)
(225) #+ %# #$ "$ $ ('$$#"!" $# # # 5;>+ ;?6. ""# $ # %" * $ ! )"##. "!$ #% 0 2#$"%$&1 ## ) & "# $ #$%" %$$ #- )$ # 34 $ $) 34 $ #$# $ !)"# $ $"#$ #5;@+;A6.
(226) #&&"#$ %#$""#)#$"!$ "#5;B6$%#%#" # ""$ #. %"$" "+
(227) # #$"%$ ! )"#) $"%$$ %$$#$#+ .. #%%"+ #$"$ '$ " $ # 3")$4. ")$ "## " $ ") "$ ' #%!" # !") &### ' 3%# $ "4+ " !" 3%# 4 " ' % # $"$ $ # 5;C6. ##$&$) # $" ) $ "!" $ ")$ #3 4+'##$$"# # "$ "3%#$ !"!$4#".$ # "$ #$ +.. &"(! #%"+ !"# ' %" ! !$ ## 3!" " $4. ! !$ ## #% #$$ $($#& '""!"# &"'.%#+! !$ ## !" $$#$%$$ #.. ;=. . 12-03-18 13:01. 15374-vdGlind_BNW.indd 13. . ;=. 12-03-18 13:01.
(228) ;. 1. ;. '""'(' "'(&#",$#')&-("""$!"((#"#( $&!'1(""')'-""&'" -&'/-$&$ '1'&)' ($"(&(#"#&(#"(#(&!"(*' -&#($&!'7;:81'' (' $&#((*(/ -$&$ '!- '(!) ( ( #)(&#+( #& - ()!#& '1 $!"((#"#('"'(&'#"+-!"-$#$ ')"(1'("""')'- ! "#-('"($&!'(($&#)!#&! "")$#",$#')&"$''(#" (#"#&"$&! '5&("#-('67<:81 . 1.
(229) .
(230) )% '""'(' %! &% % ?=, $ "'(&#",$#')&-("""$!"((#"#( $! ##* )% $' 6<A7. $ $&$$ !' 4;.=.<5 #%! $&!'1(""')'-""&'" &$#&#!!$!##%! $ -&'/-$&$ $,''1'&)' ' #$%! #!3 ($"(&(#"#&(#"(#(&!"(*' & !#%! , .. #%! $ $%! 6<B, -&#($&!'7;:81'' <C7. !" (! $ # ('!$ $&#((*(/ #!' %&# -$&$ !&%'!- %! $"* '(!) $!(# ( ( #"# #)(&#+( !
(231) #& #$ - ()!#& %# 3 '1 )"!$ $!"((#"#('"'(&'#"+-!"-$#$ *"!*%$ % ! %#!$ 6=:7, $!( ')"(1'("""')'- $ % # $ "!*!#"$$ ! "#-('"($&!'(($&#)!#&! $! !#"#!% $ '!' !&$%# "")$#",$#')&"$''(#" ##"#6=;7. (#"#&"$&! '5&("#-('67<:81
(232)
(233) .
(234) )"# % $ ##$# %(! # % ""#!$ %! & $ # # &$- ##%! "&/#!$&'" %#%#%.' !## $ "*$!!* % !# #" ! "#! '" &"#! 56 "#' '%)!#)' & $ 56 #'!" #%! %)! !&$#$%!#. &"#! 5(&#& %,$ ((& &&& (# $%"#! ' &("#-( &"#!6/ ' ( !#'( $! ! $! * *%*#' %,&$%#$&% &%%! $# !% - #!!#" #&! # "& (" +( )'"' 7<;/ <<81 ""' * '( '#*!! & $"'(#+ # !$,$"* $6=<,==7. %#$%""#! "&'"( (& #*&>:/:::"+''-&/$#'"'&#)'$) #$$#&$%%#*)"!$%!$&3$& &# !$$!#%! .$ ($&# !5 '(''#"=<:;@61'"&'"'""&""' #$$'!"$# %&#&%%! $#%!%!$!$#' !- & - ((&)( (#3$ "&'' " ')"("$" # -' (#( 5')46 (&#$'/ '"&(#"'(!",#"#)'&*&"'"&"#"''1
(235) #&"(/ & $. % !#%* 3!$$ 4$% (%!&% $& &# $5, %* '!" $ '' &%"$ #$ % $ $"* #+%!"(&*"(#"' . # % . "*'* " ''! #&4"("'* (&$' #& $&*"(* &!& %% #& " #!$!"!(%!'#)"#$$! !"?="#!% &% %! !#%! (##* #!(" (' '+ " !#&(- &#! '" "& " #&&'$#"" )&" #" $) "#$ 3)"!$ ! !# ""# 6=>7. (! ($#%# %( &1 ) *"!"(' +#) % %&!#$ '# "( ( &#+" ##&(' #&" $%!"" %*##%! $$!!%"?=3&% %!,/"?="%$0,(#!& %! (&"'$ "((#"&$"('+#&)"&!( -"&'&'#'1''#(" "#$$%,$ *($%%%$!!&$%'!" %!%&!#$.! $# %%%%&# 3 &'"!) '"')"4,$#''"&' ((&+($&)&'#& '#"'5("&(#''/ !'#%!'&# "#$$!&%(,%"#$$% !%$!(!& '60$"#!"#" '# 2 "&.(#"31 %%%%*!# %%$%#!%# $%"* $ !$%*$!#! $%$.&"?="%$'$! !& $& 3)"!$& $ ,(%#
(236)
(237)
(238)
(239)
(240)
(241) #!$$%! (#!& %!#!#3#%&%%! $ $6=?,=@7. ")!"'"'(()!#&')$$&''#&"'&$&#!""( -'"()& $! , (*"!*# ! $$%$! %%!# "#!!%!# !)((#"'5';1=1<61
GERELATEERDE DOCUMENTEN
Because we used SKH-1 hairless mice to study whether stem cells accumulate UV-induced DNA damage and play a role in UV-induced skin carcinogenesis, we first sought to explore
Door selectieve segregatie van de template strand en de nieuw gesynthetiseerde DNA strand wordt de stamcel beschermd tegen door replicatie-geïnduceerde DNA-fouten7.
In other tissues like the muscle tissue the stem cells have just been identified and the relation with stem cells and daughter cells is not entirely clear (Morgan, J. In all
A microarry study to examine the transcription profile of Vsx1 gene regulation in Type 7 bipolar cells from wild type and Vsx1-null mice would enable one to determine if there is
Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue Date:
van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue
van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue
van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue
van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue Date: 2018-04-18... unfractionated
van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue
van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue
van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue
van de Title: The role of quiescent and cycling stem cells in the development of skin cancer Issue
The Role of Quiescent and Cycling Stem Cells in the Development of Skin Cancer door Gerline van de Glind Op woensdag 18 april 2018 om 16.15u in de Senaatskamer van het
De Europese Commissie heeft meerdere stukken uitgegeven waarin wordt uitgelegd hoe staatssteun moet worden uitgelegd omtrent rulings.. In 2014 verscheen er een mededeling
H3: For those who have been exposed to a brand’s social media post in the narrative style of text (story), their familiarity will positively affect the
Gene expression in chromosomal Ridge domains : influence on transcription, mRNA stability, codon usage, and evolution..
Gene expression in chromosomal Ridge domains : influence on transcription, mRNA stability, codon usage, and evolution..
We show that disc continuum fitting can be used to constrain black hole spin in a subclass of narrow-line Seyfert 1 (NLS1) active galactic nuclei as their low mass and high
It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly
Cornu, Exact algebraic tails of static correlations in quantum plasmas at low den-..
Patients with microscopically positive resection margins, an R1 resection (defined as cases with presence of microscopic tumor cells within 1 mm of the proximal or distal
When different properties are elucidated, targeting specific CSCs without affecting normal stem cells, for example the CSC-specific signaling pathways, would be