University of Groningen
Assessment of malnutrition in patients with head and neck cancer: a multidimensional
approach
Sealy, Martine Jane
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Sealy, M. J. (2019). Assessment of malnutrition in patients with head and neck cancer: a multidimensional approach.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
$VVHVVPHQWRI0DOQXWULWLRQLQ
3DWLHQWVZLWK+HDGDQG1HFN&DQFHU
D0XOWLGLPHQVLRQDO$SSURDFK
0DUWLQH6HDO\
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© 0DUWLQH6HDO\*URQLQJHQWKH1HWKHUODQGV
$OOULJKWVUHVHUYHG1RSDUWVRIWKLV SXEOLFDWLRQVPD\EHUHSURGXFHGVWRUHGLQD UHWULHYDOV\VWHPRU WUDQVPLWWHGLQDQ\IRUPVRUDQ\PHDQVZLWKRXWWKHSULRUZULWWHQSHUPLVVLRQRIWKHFRS\ULJKWRZQHU
Assessment of malnutrition in patients
with head and neck cancer:
a multidimensional approach
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 10 april 2019 om 14.30 uur
door
Martine Jane Sealy
geboren op 21 januari 1972 te Sneek
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© 0DUWLQH6HDO\*URQLQJHQWKH1HWKHUODQGV
$OOULJKWVUHVHUYHG1RSDUWVRIWKLV SXEOLFDWLRQVPD\EHUHSURGXFHGVWRUHGLQD UHWULHYDOV\VWHPRU WUDQVPLWWHGLQDQ\IRUPVRUDQ\PHDQVZLWKRXWWKHSULRUZULWWHQSHUPLVVLRQRIWKHFRS\ULJKWRZQHU
Assessment of malnutrition in patients
with head and neck cancer:
a multidimensional approach
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 10 april 2019 om 14.30 uur
door
Martine Jane Sealy
geboren op 21 januari 1972 te Sneek
3URPRWRUHV
3URIGU-/15RRGHQEXUJ 3URIGU&3YDQGHU6FKDQV&RSURPRWRU
'U+-DJHU:LWWHQDDU%HRRUGHOLQJVFRPPLVVLH
3URIGU*-1DYLV 3URIGU)./6SLMNHUYHW 3URIGU00XVFDULWROL3DUDQLPIHQ
/LHVWHU%HHN :LOOHPNH1LMKROW
3URPRWRUHV
3URIGU-/15RRGHQEXUJ 3URIGU&3YDQGHU6FKDQV&RSURPRWRU
'U+-DJHU:LWWHQDDU%HRRUGHOLQJVFRPPLVVLH
3URIGU*-1DYLV 3URIGU)./6SLMNHUYHW 3URIGU00XVFDULWROL3DUDQLPIHQ
/LHVWHU%HHN :LOOHPNH1LMKROW
7DEOHRIFRQWHQWV
&KDSWHU ,QWURGXFWLRQ &KDSWHU /LPLWHGFRQWHQWYDOLGLW\DFURVVPHWKRGVRIPDOQXWULWLRQDVVHVVPHQW LQSDWLHQWVZLWKFDQFHU DV\VWHPDWLFUHYLHZ -RXUQDORI&OLQLFDO(SLGHPLRORJ\ &KDSWHU 7UDQVODWLRQDQGFXOWXUDODGDSWDWLRQRIWKH6FRUHG3DWLHQW*HQHUDWHG 6XEMHFWLYH*OREDO$VVHVVPHQW 3*6*$ DQLQWHUGLVFLSOLQDU\ QXWULWLRQDOLQVWUXPHQWDSSURSULDWHIRU'XWFKFDQFHUSDWLHQWV &DQFHU1XUVLQJ&KDSWHU (YDOXDWLRQRIFKDQJHLQGietitians’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
7DEOHRIFRQWHQWV
&KDSWHU ,QWURGXFWLRQ &KDSWHU /LPLWHGFRQWHQWYDOLGLW\DFURVVPHWKRGVRIPDOQXWULWLRQDVVHVVPHQW LQSDWLHQWVZLWKFDQFHU DV\VWHPDWLFUHYLHZ -RXUQDORI&OLQLFDO(SLGHPLRORJ\ &KDSWHU 7UDQVODWLRQDQGFXOWXUDODGDSWDWLRQRIWKH6FRUHG3DWLHQW*HQHUDWHG 6XEMHFWLYH*OREDO$VVHVVPHQW 3*6*$ DQLQWHUGLVFLSOLQDU\ QXWULWLRQDOLQVWUXPHQWDSSURSULDWHIRU'XWFKFDQFHUSDWLHQWV &DQFHU1XUVLQJ&KDSWHU (YDOXDWLRQRIFKDQJHLQGietitians’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
