University of Groningen
Crosstalk of the mTOR network with stress granules and the TGF-beta pathway
Prentzell, Mirja Tamara
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
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Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Prentzell, M. T. (2018). Crosstalk of the mTOR network with stress granules and the TGF-beta pathway.
University of Groningen.
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University of Groningen
Crosstalk of the mTOR network with stress granules and the TGF-beta pathway
Prentzell, Mirja
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from
it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date:
2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Prentzell, M. T. (2018). Crosstalk of the mTOR network with stress granules and the TGF-beta pathway
[Groningen]: University of Groningen
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Propositions
to accompany the dissertation Crosstalk of the mTOR network with stress granules and the TGF-beta pathway1. mTOR, stress granules, and TGF-beta signaling represent central cellular signaling hubs essential for normal cell viability, and implicated in tumorigenesis (this thesis).
2. The development of more effective therapeutic strategies requires the identification of convergence points between mTOR and other oncogenic signaling cascades (this thesis).
3. This proposition is deliberately invisible.
4. TSC1 links insulin-Akt signaling to the TGF-beta-Smad2/3 pathway (this thesis).
5. Even though TSC1 or TSC2 mutations are considered redundant for their effects in the mTORC1 pathway, they evoke different TGF-beta pathway responses (this thesis).
6. RNA granules: the good, the bad and the ugly (Thomas et al. 2011). 7. TGF-beta - an excellent servant but a bad master (Kubiczkova et al. 2012). 8. It doesn’t matter how beautiful your theory is, it doesn’t matter how smart you are. If it doesn’t agree with experiment, it’s wrong (Richard Feynman).
9. Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less (Marie Curie).
10. Learn from yesterday, live for today, hope for tomorrow. The important thing is not to stop questioning (Albert Einstein).
11. Nothing in biology makes sense except in the light of evolution ( Theodosius Dobzhansky).
Mirja Tamara Prentzell Groningen, May 7, 2018
