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Molecular alterations during cervical carcinogenesis
Verlaat, W.
2018
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citation for published version (APA)
Verlaat, W. (2018). Molecular alterations during cervical carcinogenesis: Identification of novel biomarkers for
triage in HPV-based cervical screening.
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ChApTEr
10
Curriculum Vitae & List of
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Chapter 10 CV & List of Publications
C U r r I C U L U M V I TA E
Wina Verlaat was born in Wognum on January 1, 1988. She went to secondary school (VWO) at the Oscar Romero Tabor College in Hoorn. After graduation in 2006, she started her bachelor Biomedical Sciences at the VU University in Amsterdam. During this study, she did an internship at the department of Medical Microbiology and Infection Control of the VU University, supervised by Aniek van der Woude and Wilbert Bitter PhD. She graduated cum laude for her Bachelor of Science degree in 2009. Afterwards, she started her master Oncology at the VU University Medical Centre (VUmc) in Amsterdam. In the first year, she did an internship at the department of Pathology, unit Molecular Pathology of the VUmc. She worked on a project about altered expressed miRNAs and methylation-mediated repression of miRNAs during cervical carcinogenesis, supervised by Saskia M. Wilting PhD and Renske D.M. Steenbergen PhD. In the second year, she went to Boston, MA, United States of America for an internship at the division of Infectious Diseases of Brigham and Women’s Hospital and Harvard Medical School. Under supervision of Molly E. McLaughlin-Drubin PhD and Karl Münger PhD, she worked on a project about the composition of polycomb repressive complexes in presence and absence of HPV E7. She received her Master of Science degree in 2011. Afterwards, she worked one year as a research technician at the department of Pathology, unit Molecular Pathology of the VUmc and subsequently started her PhD project at the same department, under supervision of Renske D.M. Steenbergen PhD, Peter J.F. Snijders† PhD, Chris J.L.M. Meijer PhD and Daniëlle A.M. Heideman PhD. The results of this PhD project are described in this thesis. Currently, she works as a scientific officer at Self-screen B.V.
L I S T O F p U B L I C AT I O N S
1. Saskia M. Wilting, Peter J.F. Snijders, Wina Verlaat, Annelieke Jaspers, Mark A. van
de Wiel, Wessel N. van Wieringen, Gerrit A. Meijer, Gemma G. Kenter, Yajun Yi, Carlos le Sage, Reuven Agami, Chris J.L.M. Meijer and Renske D.M. Steenbergen. Altered microRNA expression associated with chromosomal changes contributes to cervical carcinogenesis. Oncogene 2013; 32(1): 106-116.
2. Saskia M. Wilting, Wina Verlaat, Annelieke Jaspers, Nour A. Makazaji, Reuven Agami,
Chris J.L.M. Meijer, Peter J.F. Snijders and Renske D.M. Steenbergen. Methylation-mediated transcriptional repression of microRNAs during cervical carcinogenesis.
Epigenetics 2013; 8(2): 220-228.
3. Wina Verlaat, Peter J.F. Snijders, Marinda I.H. van Moorsel, Maaike C.G. Bleeker,
Lawrence Rozendaal, Daoud Sie, Bauke Ylstra, Chris J.L.M. Meijer, Renske D.M. Steenbergen and Daniëlle A.M. Heideman. Somatic mutation in PIK3CA is a late event in cervical carcinogenesis. Journal of Pathology: Clinical Research 2015; 1(4): 207-211. 4. Mark A. van de Wiel, Tonje G. Lien, Wina Verlaat, Wessel N. van Wieringen and Saskia
M. Wilting. Better prediction by use of co-data: Adaptive group-regularized ridge regression. Statistics in Medicine 2016; 35(3): 368-381.
5. Wina Verlaat, Peter J.F. Snijders, Putri W. Novianti, Saskia M. Wilting, Lise M.A. De
Strooper, Geert Trooskens, Johan Vandersmissen, Wim Van Criekinge, G. Bea A. Wisman, Chris J.L.M. Meijer, Daniëlle A.M. Heideman and Renske D.M. Steenbergen. Genome-wide DNA methylation profiling reveals methylation markers associated with 3q gain for detection of cervical precancer and cancer. Clinical Cancer Research
2017;23(14):3813-3822.
6. Wina Verlaat, Barbara C. Snoek, Daniëlle A.M. Heideman, Saskia M. Wilting, Peter
J.F. Snijders, Putri W. Novianti, Annina P. van Splunter, Carel F.W. Peeters, Nienke E. van Trommel, Leon F.A.G. Massuger, Ruud L.M. Bekkers, Willem J.G. Melchers, Folkert J. van Kemenade, Johannes Berkhof, Mark A. van de Wiel, Chris J.L.M. Meijer and Renske D.M. Steenbergen. Identification and validation of a 3-gene methylation classifier for HPV-based cervical screening on self-samples. Clinical Cancer Research
2018; 24(14): 3456-3464.
7. Wina Verlaat, Robert W. van Leeuwen, Putri W. Novianti, Ed Schuuring, Chris J.L.M.
Meijer, Ate G. J. van der Zee, Peter J.F. Snijders, Daniëlle A.M. Heideman, Renske D. M. Steenbergen and G. Bea A. Wisman. Host cell DNA methylation patterns during high-risk HPV-induced carcinogenesis reveal a heterogeneous nature of cervical precancer.
Epigenetics 2018; 13(7): 769-778.
8. Barbara C. Snoek, Wina Verlaat, Iris Babion, Putri W. Novianti, Mark A. van de Wiel,
Saskia M. Wilting, Nienke E. van Trommel, Maaike C.G. Bleeker, Leon F.A.G. Massuger, Willem J.G. Melchers, Daoud Sie, Daniëlle A.M. Heideman, Peter J.F. Snijders, Chris J.L.M. Meijer and Renske D.M. Steenbergen. Genome-wide microRNA analysis of HPV-positive self-samples yields novel triage markers for early detection of cervical cancer.
International Journal of Cancer 2018; DOI: 10.1002/ijc.31855.
218 219
Chapter 10 CV & List of Publications
9. Wieke W. Kremer, Marjolein van Zummeren, Putri W. Novianti, Karin L. Richter, Wina Verlaat, Peter J.F. Snijders, Daniëlle A.M. Heideman, Renske D.M. Steenbergen, Greta
Dreyer and Chris J.L.M. Meijer. Detection of hypermethylated genes as markers for cervical screening in women living with HIV. Journal of the International AIDS Society
2018; 21(8): e25165.
10. Barbara C. Snoek, Annina P. van Splunter, Maaike C.G. Bleeker, Maartje C. van Ruiten, Daniëlle A.M. Heideman, Rik Rurup, Wina Verlaat, Hans Schotman, Mignon van Gent,
Nienke E. van Trommel and Renske D.M. Steenbergen. Cervical cancer detection by DNA methylation analysis in urine. Submitted for publication.
