University of Groningen Role of quantitative and gated myocardial perfusion PET imaging Monroy-Gonzalez, A. G.

University of Groningen

Role of quantitative and gated myocardial perfusion PET imaging

Monroy-Gonzalez, A. G.

DOI:

10.33612/diss.132603282

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Publication date:

2020

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Monroy-Gonzalez, A. G. (2020). Role of quantitative and gated myocardial perfusion PET imaging.

University of Groningen. https://doi.org/10.33612/diss.132603282

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Role of Quantitative

and Gated Myocardial

Perfusion PET Imaging

Colofon

Role of quantitative and gated myocardial perfusion PET imaging, Andrea De Guadalupe Monroy Gonzalez

Copyright © 2020 Andrea De Guadalupe Monroy Gonzalez

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.

The research reported in this thesis was carried out in the Department of Nuclear medicine and Molecular Imaging of the University Medical Center Groningen.

The research reported in this thesis was financially supported by the Abel Tasman Talent Program and the Mexican National Council of Science and Technology (CONACYT).

Printing of this thesis was financially supported by the Graduate School of Medical Sciences and the University Medical Center Groningen.

Cover image: Jonathan Gómez

Layout and design by Eva Huijts, persoonlijkproefschrift.nl Printing: Ridderprint | www.ridderprint.nl

Role of quantitative and gated

myocardial perfusion PET imaging

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. C. Wijmenga

and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 21 September 2020 at 18.00 hours

by

Andrea De Guadalupe Monroy Gonzalez

born on 14 August 1990 in Mexico City, Mexico

SUPERVISORS

Prof. R.H.J.A. Slart Prof. E. Alexanderson

Co-supervisors

Prof. R.A. Tio Prof. N.H.J. Prakken

Assessment Committee

Prof. A.A. Voors Prof. R. Boellaard Prof. L. Stegger

Paranymphs

Verena Böhmer

CONTENTS

Part I: Introduction

Chapter 1 General introduction: PET/CT with 13_{N-ammonia 11}

Part II: Quantitative myocardial perfusion imaging

Chapter 2 Software reproducibility of myocardial blood flow and flow reserve quantification in ischemic heart disease: A 13_{N-ammonia PET study}

24

Chapter 3 Long-term prognostic value of quantitative myocardial perfusion in patients with chest

pain and normal coronary arteries 48 Chapter 4 Myocardial bridging of the left anterior descending coronary artery is associated with reduced

myocardial flow reserve: A 13_{N-ammonia PET study}

68

Chapter 5 Relationship between transluminal attenuation gradient and quantitative myocardial perfusion:

A proof of concept study with 13_{N-ammonia PET} 92

Part III: Ventricular synchrony

Chapter 6 Phase analysis of gated PET in the evaluation of mechanical ventricular synchrony: A narrative

overview 114

Chapter 7 Ventricular synchrony is not significantly determined by absolute myocardial perfusion in patients with chronic heart failure: A 13_{N- ammonia PET study}

134

Part IV: Overview and discussion

Chapter 8 Concluding remarks and future perspectives 158

Chapter 9 Summary 168

Chapter 10 Nederlandse samenvatting 172

Part V: Appendices

Chapter 11 Acknowledgments 180 Chapter 12 Curriculum vitae 186 Chapter 13 List of publications 190

PART