University of Groningen
Mechanism of the translocon Taufik, Intan
DOI:
10.33612/diss.102814953
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Taufik, I. (2019). Mechanism of the translocon: events at the gate. University of Groningen. https://doi.org/10.33612/diss.102814953
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Propositions
Belonging to the PhD thesis
Mechanism of Translocon Events at The Gate
Intan Taufik
1. Mechanistic studies of canonical bacterial protein transport come into full circle, from in vivo to in vitro, back to in vivo. (Chapter 1)
2. The lateral gate is highly flexible but needs to be coordinated to open to its full length from its cis, mid and trans section, to allow protein translocation. (Chapter 2)
3. The cytosolic interface of the SecYEG channel is more sensitive to mutations and chemical modification as compared to its periplasmic interface. (Chapter 3) 4. Monomeric SecYEG is functional for protein translocation. (Chapter 4)
5. The two-helix finger domain of SecA plays an important role in initial interaction between SecA, substrate protein and Sec translocon. (Chapter 5)
6. Imagination is an excellent tool for trying to elucidate nature’s mechanism, especially those that cannot be seen directly.
7. Manscape does not only exist in human-civilization size ecosystem, but also in molecular system.
8. Cycling is a fast way to find a reason to buy new pants.
9. Every topic is interesting, until a point that you stumble onto an itch that you know it can be done, but that is not what you are experiencing.
