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Meanwhile, newly syn- thesized MHC-II would traffic to these late compart- ments but avoid being sorted into ILVs due to suppressed ubiquitination [ 32 ], remaining instead on

Since murine skin does not form a reliable marker for immune responses in human skin, we used human skin explants to study the interaction with non-attenuated and RA cercariae

All the conjugates with the mannoside clusters and the TLR7 ligand induced the expression of the moDCs maturation marker CD86 (Figure 5C), as well as CD83 (Supplementary Figure

Proteomic analysis of latex bead–containing phagosomes in the J774 cell line has shown that CatB, CatS, CatL, and CatZ are in- deed the most abundant cysteine proteases

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Chapter 5 FcgR ligation on dendritic cells induces broad immune response gene 73 signature tightly regulated by FcgRIIb. Chapter 6 Antigen storage compartments in mature

Synthesis of trifunctional mannosylated peptide antigen conjugates targeting DC-SIGN and

This Thesis presents studies on the targeting of mannosylated conjugates to C-type lectin receptors (CLRs) present on antigen presenting cells.. Chapter 2 describes a