Cover Page
The handle http://hdl.handle.net/1887/65054 holds various files of this Leiden University dissertation.
Author: Kantae, V.
Title: Systems pharmacology of the endocannabinoid system Issue Date: 2018-09-06
Systems Pharmacology of the Endocannabinoid System
Vasudev Kantae
Publication of this thesis was financially sponsored by:
SCIEX
Leiden Academic Centre for Drug Research (LACDR)
ISBN: 978-94-92679-53-6
© Vasudev Kantae, Leiden, the Netherlands
Cover design: Fred Frij & Vasudev Kantae
Printed by: Print Service Ede
Systems Pharmacology of the Endocannabinoid System
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus Prof. Mr. C.J.J.M. Stolker,
volgens besluit van het college voor Promoties
te verdedigen op donderdag 6 September 2018
Klokke 10:00 uur.
door
Vasudev Kantae
geboren te Vetlapalem, Indië in 1986
PROMOTOR
Prof. dr. Thomas Hankemeier
Prof. dr. Piet H van der Graaf
CO-PROMOTOR
Dr. Amy C Harms
PROMOTIECOMMISSIE
Prof. dr. Hubertus Irth (Chair)
Leiden University, the Netherlands
Prof. dr. Joke Bouwstra (Secretary)
Leiden University, the Netherlands
Prof. dr. Renger Witkamp
Wageningen University, the Netherlands
Prof. dr. Catherijne Knibbe
Leiden University, the Netherlands
Prof. dr. Mario van der Stelt
Leiden University, the Netherlands
Prof. dr. Patrick Rensen
Leiden University Medical Center (LUMC), the Netherlands
The research received support from the Faculty of Science (“Profiling Programme:
Endocannabinoids”), Leiden University, the Netherlands
.
Contents
Chapter 1
Introduction: Systems pharmacology of the endocannabinoid system 1
Chapter 2
Pharmacometabolomics informs pharmacokinetics and 17
pharmacodynamics: toward personalized drug therapy
Chapter 3
Quantitative profiling of endocannabinoids and related N-acylethanolamines 37 in human CSF using nano LC-MS/MS
Chapter 4
Investigating the players of 2-arachidonyl glycerol biosynthesis in cellular system 65
Chapter 5
Activity-based protein profiling reveals off-target proteins 81 of the FAAH inhibitor BIA 10-2474
Chapter 6
Pharmacokinetic Modeling of Paracetamol Uptake and Clearance 135 in Zebrafish Larvae: Expanding the Allometric Scale in Vertebrates
with Five Orders of Magnitude
Chapter 7
System pharmacology of an endocannabinoid system modulator 155 in zebrafish larva
Chapter 8
Endocannabinoid tone is higher in healthy lean South Asian 177 than white Caucasian men
Chapter 9
Conclusion and future prospects 197
Appendix
Summary 212
Nederlandse Samenvatting 216
Dankwoord / Acknowledgements 221
Curriculum Vitae 223
List of publications 224
