University of Groningen
New molecular mechanisms of aging regulation Sen, Ilke
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Publication date: 2018
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Sen, I. (2018). New molecular mechanisms of aging regulation. University of Groningen.
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New molecular
mechanisms of aging
regulation
The printing of this thesis was financially supported by:
University of Groningen, The Netherlands
Graduate school for drug exploration GUIDE, Groningen, The Netherlands
Copyright Ilke Sen 2018
Printed by: ProefschriftMaken || www.proefschriftmaken.nl ISBN (print) : 978-94-93019-85-0
New molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelNew molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelNew molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelNew molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelNew molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelNew molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelNew molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelNew molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelAssessment Committee
Prof. H.H. Kampinga Prof. E.A.A. Nollen Prof. B.M.T. Burgering
New molecular mechanisms
of aging regulation
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Monday 22 October 2018 at 12.45 hours by
Ilke Sen
born on 17 April 1987 in Izmir, Turkey Supervisors Prof. G. de Haan Prof. P.M. Lansdorp Co-supervisor Dr. C.G. RiedelParanymphs
Nataly Puerta Cavanzo Jakub Wudarski
TABLE OF CONTENTS
Chapter 1 Introduction 9
Chapter 2 Regulation of age-related decline by transcription factors 25
and their crosstalk with the epigenome Chapter 3 DAF-16/FOXO and HLH-30/TFEB function as 61
combinatorial transcription factors to promote stress resistance and longevity Chapter 4 DAF-16 requires Protein Phosphatase 4 to initiate the 105
transcription of stress resistance and longevity promoting genes Chapter 5 General discussion and future perspectives 159
Chapter 6 Summary 169
Chapter 7 Nederlandse samenvatting 173
Appendices: List of abbreviations 177
