University of Groningen
Epidemiology, genetic diversity and clinical manifestations of arboviral diseases in Venezuela
Lizarazo, Erley F.
DOI:
10.33612/diss.108089934
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Lizarazo, E. F. (2019). Epidemiology, genetic diversity and clinical manifestations of arboviral diseases in Venezuela. University of Groningen. https://doi.org/10.33612/diss.108089934
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Stellingen
Behorende bij het proefschrift
Epidemiology, genetic diversity and clinical manifestations of arboviral diseases in Venezuela:
1. Our analysis suggests that the epidemic of chikungunya followed a specific spatial pathway with spatiotemporal aggregation. (This thesis)
2. Population density modulates the chance of vector–host contact. This is reflected in the variation of calculated velocities across different spatial points and the increased diffusion speed of the chikungunya epidemic in the most populated areas of Valencia city, Venezuela. (This thesis)
3. In Venezuela, the concomitant epidemics of dengue and chikungunya studied here depicted similar temporal and spatial dynamics probably defined by mosquito seasonality and heterogeneity. (This thesis) 4. Shotgun metagenomics is suitable for identification and typing of dengue virus in a clinical setting. (This thesis)
5. The ability to detect multiple dengue serotypes together with the high throughput of next generation sequencing technologies could facilitate the in-depth analysis of co-viral infections and their relation with clinical manifestations. (This thesis)
6. DEN-IM is a user-friendly automated workflow for analysis of next generation sequencing data that enables reproducible and collaborative research, being accessible to a wide group of researchers regardless of their computational expertise and resources available. (This thesis)
7. The sequential introduction of different dengue virus serotypes in the country and the increased frequency of dengue outbreaks has shaped the genetic diversity of dengue virus populations in Venezuela. (This thesis)
8. Better methods are required to study/monitor arboviral diseases not only in the clinical diagnostic laboratory but also in its natural environment (either urban or enzootic cycle). (This thesis)
9. “Basic research is what I'm doing when I don't know what I'm doing”. Wernher von Braun 10. “Religion is a culture of faith; science is a culture of doubt.” Richard P. Feynman
11. “Success is a science; if you have the conditions, you get the result”. Oscar Wilde
