University of Groningen
Sensing dengue and chikungunya virus (co-) infections
Aguilar Briseño, Alberto
DOI:
10.33612/diss.172910464
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Publication date:
2021
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Aguilar Briseño, A. (2021). Sensing dengue and chikungunya virus (co-) infections. University of
Groningen. https://doi.org/10.33612/diss.172910464
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Sensing dengue and chikungunya virus
(co-) infections
The research presented in this thesis was conducted at the Department of Medical Microbiology and Infection Prevention of the University Medical Center Groningen within the Groningen University Institute for Drug Exploration (GUIDE), University of Groningen, Groningen, the Netherlands.
Part of this work has been supported by the NWO-Veni grant, the Research grant 2019 from the European Society of Clinical Microbiology and Infectious Diseases (ECSMID), the Jan Kornelis de Kock foundation (Groningen) and Consejo Nacional de Ciencia y Tecnología (CONACYT, México)
The printing of this thesis was fi nancially supported by the University of Groningen and the Graduate School of Medical Sciences.
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Copyright © 2021 by José Alberto Aguilar Briseño
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Sensing dengue and chikungunya virus (co-) infections
PhD Thesis
to obta in the degree of PhD at the University of Groningen
on the authority of the Rector Magnifi cus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This th esis will be defended in public on
Monday 5 July 2021 at 14:30 hours
by
José Alberto Aguilar Briseño
born on 3 December 1986 in San Luis Potosi, Mexico
Supervisor Prof. J.M. Smit Co-supervisor Dr. I.A. Rodenhuis-Zybert Assessment Committee Prof. A. Kohl Prof. A. van der Ven Prof. P. Heeringa
Paranymphs
Amrita Singh
Table of contents
Chapter 1 Introduction and scope of the thesis 9
Chapter 2 Suppression of chikungunya virus replication and differential innate responses of human peripheral blood mononuclear cells during co-infection with dengue virus
37
Chapter 3 Rewiring PBMC responses to prevent CHIKV infection-specific
monocyte subset redistribution and cytokine responses 63
Chapter 4 TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis
87
Chapter 5 Immature dengue virus particles trigger innate immune responses in peripheral blood mononuclear cells through TLR2/TLR6/CD14 signaling axis
139
Chapter 6 Summarizing discussion 171
Appendix
Nederlandse samenvatting 196
Acknowledgements 199
Curriculum Vitae 202
