University of Groningen MIF-CD74 interaction as a promising target in drug discovery Go, Tjie Kok

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University of Groningen

MIF-CD74 interaction as a promising target in drug discovery

Go, Tjie Kok

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Publication date: 2019

Link to publication in University of Groningen/UMCG research database

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Go, T. K. (2019). MIF-CD74 interaction as a promising target in drug discovery. University of Groningen.

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526013-L-bw-Kok_proef_23nov 526013-L-bw-Kok_proef_23nov 526013-L-bw-Kok_proef_23nov 526013-L-bw-Kok_proef_23nov Processed on: 23-11-2018 Processed on: 23-11-2018 Processed on: 23-11-2018

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MIF-CD74 interaction

as a promising target in drug discovery

Tjie Kok

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The research described in this thesis was conducted in the Department of Chemical and Pharmaceutical Biology at the University of Groningen and supported financially by Directorate General of Higher Education Indonesia (DIKTI) in collaboration with the University of Surabaya (Ubaya), Indonesia and the University of Groningen (RuG), The Netherlands.

Printing of this thesis was funded by the University Library and the Graduate School of Science and Engineering, University of Groningen (RuG), The Netherlands.

ISBN (printed version): 978-94-034-1227-6 ISBN (electronic version): 978-94-034-1226-9 Layout and cover: Tjie Kok

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MIF-CD74 interaction

as a promising target in drug discovery

PhD thesis

to obtain the degree of PhD

at the University of Groningen

on the authority of the

Rector Magnificus Prof. E. Sterken

and in accordance with

the decision by the College of Deans.

This thesis will be defended in public on

Friday 25 January 2019 at 16.15 hours

by

Tjie Kok

born on 20 August 1969

in Surabaya, Indonesië

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Supervisors

Prof. dr. F.J. Dekker Prof. dr. G.J. Poelarends Assessment Committee

Prof. dr. Martina Schmidt Prof. dr. Roland Pieters Prof. dr. Peter Olinga

Paranymphs:

Joko P. Wibowo Lieuwe Biewenga

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Uw woord is een lamp voor mijn voet, een licht voor mijn pad

Psalmen 119:105 (Statenvertaling)

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Table of Contents

Chapter 1. Introduction and scope of the thesis

Chapter 2. Small-molecule inhibitors of MIF as a potential class of therapeutics for inflammatory diseases and cancer

Chapter 3. High yield production of human CD74 as fusion proteins

Chapter 4. Development of chromenes as MIF inhibitors

Chapter 5. Synthesis of a focused compound collection of isoxazole, benzoxazole and triazole-phenol scaffolds to explore the structure-activity relationship for MIF tautomerase structure-activity inhibition

Chapter 6. Summary and future perspectives

Appendices

Acknowledgements List of publications About the author