University of Groningen
Cellular Stress in Aging and Cancer Sturmlechner, Ines
DOI:
10.33612/diss.170212168
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Sturmlechner, I. (2021). Cellular Stress in Aging and Cancer. University of Groningen. https://doi.org/10.33612/diss.170212168
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1. Chronic cellular stress drives tissue dysfunction and causes aging and disease. This thesis
2. Cellular senescence is an evolving cell fate with beneficial and/or detrimental properties. This thesis
3. P21 is a multifaceted protein that provokes immunosurveillance. This thesis
4. Targeting of senescent cells for therapeutic purposes requires a deep understanding of associated molecular mechanisms. This thesis 5. Omics approaches such as RNA-seq or ChIP-seq are powerful hypothesis-generating tools. This thesis
6. Aneuploidy is a hallmark of aging and cancer, however, it does not dictate severity or disease alone. This thesis
7. CCNE1 is a liver-specific oncogene that drives hepatocellular carcinoma development via multiple mechanisms. This thesis 8. BUBR1 protein levels alone do not dictate phenotypic severity. This thesis
9. Our responsibility is to do what we can, learn what we can, improve the solution and pass them on. Richard Feynman
