University of Groningen
Cellular Stress in Aging and Cancer
Sturmlechner, Ines
DOI:
10.33612/diss.170212168
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Sturmlechner, I. (2021). Cellular Stress in Aging and Cancer. University of Groningen. https://doi.org/10.33612/diss.170212168
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Cellular Stress in Aging and Cancer
The research described in this thesis was mainly conducted at the Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota, United States of America. The research described in this thesis was partially financially supported by Mayo Clinic’s Center for Biomedical Discovery, the Paul F. Glenn Foundation for Medical Research, The Keck Foundation, and the United States National Institutes of Health (grants R01 AG057493, R01 AG043263, R01 CA096985, R01 CA166347, R01 CA126828), Unity Biotechnology, the Mayo Clinic Graduate School of Biomedical Sciences, The Groningen University Institute for Drug Exploration (GUIDE) and the University of Groningen.
Cover design: Ines Sturmlechner via BioRender Interior design: Ines Sturmlechner
Printing: by Gildeprint – The Netherlands
© Ines Sturmlechner, 2021
No part of this book may be reproduced, stored in retrieval systems, or transmitted in any form or by any means without prior permission of the author, or, where applicable, the publisher holding the
Cellular Stress in Aging and Cancer
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Monday 7 June 2021 at 14.30 hours
by
Ines Sturmlechner
born on 27 June 1990
in Krems an der Donau, Austria
Supervisors
Prof. A.J.A. van de Sluis Prof. B.F. Horazdovsky
Assessment Committee
Prof. F. Kuipers Prof. G. de Haan Prof. N. Riksen
Table of contents
Chapter 1 General introduction 7
Chapter 2 Cellular senescence in renal ageing and disease 19
Chapter 3 Two-step senescence-focused cancer therapies 45
Chapter 4 Senescent cells in the development of cardiometabolic disease 63
Chapter 5 p21 produces a bioactive secretome that places stressed cells
under immunosurveillance
81
Chapter 6 BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome
119
Chapter 7 Ccne1 overexpression causes chromosome instability in liver cells and liver tumor development in mice
157
Chapter 8 FoxM1 insufficiency hyperactivates Ect2–RhoA–mDia1 signaling to drive cancer
189
Chapter 9 General discussion 229
Appendices Summary 241
Nederlandse samenvatting 245
Acknowledgements 247
List of publications 252
