University of Groningen
Biological interactions in depression: Insights from preclinical studies Moraga Amaro, Rodrigo
DOI:
10.33612/diss.165782986
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Publication date: 2021
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Moraga Amaro, R. (2021). Biological interactions in depression: Insights from preclinical studies. University of Groningen. https://doi.org/10.33612/diss.165782986
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1. Development of PET tracers for new targets in depression is necessary to determine the contribution of individual biological targets to the brain molecular interactions of depressed patients. (Chapter 2)
2. When working with stress models, even the slightest change in the protocol may affect the reproducibility and affect the outcome of the experiment. (Chapters 4-7)
3. The lack of long-term depressive-like behavior observed in stress-based preclinical models of depression can offer an opportunity for a new model of a different feature of the same disease, as this
apparent disadvantage could be used as a natural remission model. (Chapter 7)
4. Special attention should be given to pharmacological therapies prescribed to pregnant woman, as they may induce permanent impairments in their offspring. (Chapter 8).
5. Studies on the biology of depression should focus on
understanding the similarities and differences in the biological mechanisms found between animal models and patients who suffer from depression, to understand better the limitations of preclinical studies.
6. Because of the multifactorial nature and diverse symptomatology, depressive disorders should be diagnosed as a spectrum of disorders instead of different types of specific disorders.
7. The dose is important; recreational drugs of abuse at low doses can be used as potential treatments for mood disorders, including depression.
8. Good science is not about obtaining the expected results, but about what you can learn from the results you obtained.
9. Negative results should also be published in high impact peer-reviewed journals to avoid repetition of non-published research and improve the pace of scientific discoveries.
10. The more we know about the brain, the more we realize how far we are from understanding how it works.
