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University of Groningen

Biological interactions in depression: Insights from preclinical studies Moraga Amaro, Rodrigo

DOI:

10.33612/diss.165782986

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Moraga Amaro, R. (2021). Biological interactions in depression: Insights from preclinical studies. University of Groningen. https://doi.org/10.33612/diss.165782986

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Biological interactions in depression:

Insights from preclinical studies

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Brain molecular interactions in depression: insights from preclinical studies Rodrigo Esteban Moraga Amaro (Rodrigo Moraga-Amaro)

Copyright © 2020 Rodrigo Esteban Moraga Amaro

All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any way or by any means without the prior permission of the author, or when applicable, of the publishers of the scientific papers.

The research reported in this thesis was carried out in the Department of Nuclear medicine and Molecular Imaging of the University Medical Center Groningen (UMCG) and the Laboratorio de Neurobiología, Facultad de Ciencias de la Salud, Universidad Andres Bello (UNAB). The research reported in this thesis was financially supported by the Agencia Nacional de Investigación y Desarrollo (ANID, ex-CONICYT), Programa de formación de capital humano avanzado, Becas Chile en el extranjero.

Cover image: Carolina Soto Comte

Layout and design by Carolina Soto Comte and Rodrigo Moraga Amaro. Printing: GVO drukkers & vormgevers https://www.gvo.nl/

Printing of this thesis was financially supported by the Graduate School of Medical Sciences and the University Medical Center Groningen.

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Biological interactions in depression:

Insights from preclinical studies

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the

Rector Magnificus Prof. C. Wijmenga and in accordance with

the decision by the College of Deans. This thesis will be defended in public on

Monday 19 April 2021 at 14.30 hours

by

Rodrigo Moraga Amaro

born on 26 May 1989 in Quinta Normal, Chile

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Supervisors

Prof. E.F.J. de Vries Prof. R.A.J.O. Dierckx

Co-supervisors

Dr. J. Doorduin Dr. J. Stehberg

Assessment Committee

Prof. J. Booij

Prof. I.E.C. Sommer Prof. A. Dagnino-Subiabre

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Table of contents

Chapter 1.

Introduction………...….6

Chapter 2.

Sex steroid hormones and brain function: PET imaging

as a tool of research………..…………40

Chapter 3.

Ovariectomy-induced depressive-like behavior and brain

glucose metabolism changes in female rats are not affected

by chronic mild stress………...………68

Chapter 4.

Ketamine as an antidepressant: effects on stress-induced

neuroinflammation ………..…..…….….…88

Chapter 5.

Comparison of TSPO PET tracers [

11

C]-PK11195 and

[

11

C]-PBR28 for measurement of neuroinflammation in

the repeated social defeat rat model of depression ………..….…110

Chapter 6.

Exploring the link between caffeine and neuroinflammation

using the repeated social defeat stress model in the rat…..…...…128

Chapter 7.

Enhanced dopamine D

2

/D

3

receptor and serotonin transporter

availability after recovery from repeated social defeat

induced anhedonic behavior……….………..…..…..……154

Chapter 8.

Prenatal Fluoxetine impairs non-hippocampal but not

hippocampal memory in adult male rat offspring…….…………176

Chapter 9.

Discussion……….…...……..…200

Chapter 10.

English summary………...….………..……226

Chapter 11.

Nederlandse Samenvatting………...……234

Chapter 12.

Resumen en español……….……242

Chapter 13

. Acknowledgements/Agradecimientos……..………252

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