Developmental care and very preterm infants : neonatal, neurological, growth and developmental outcomes

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(1)Developmental care and very preterm infants : neonatal, neurological, growth and developmental outcomes Maguire, C.M.. Citation Maguire, C. M. (2008, April 17). Developmental care and very preterm infants : neonatal, neurological, growth and developmental outcomes. Retrieved from https://hdl.handle.net/1887/12703 Version:. Corrected Publisher’s Version. License:. Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded from:. https://hdl.handle.net/1887/12703. Note: To cite this publication please use the final published version (if applicable)..

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(11) "3BOEPNJ[FE$POUSPMMFE5SJBMFYBNJOJOHUIF&GGFDUTPG/*%$"1. 5BCMF*OGBOUNFEJDBMCBDLHSPVOEWBSJBCMFTPGBMMQBSUJDJQBUJOHJOGBOUT. #JSUI$IBSBDUFSJTUJDT. /*%$"1 O. $ O. (FTUBUJPOBMBHF NFBOJOXLT TE SBOHF. O . ¬. O . . #JSUIXFJHIU NFBOJOH TE SBOHF. O . . O . . -FOHUI NFBOJODN TE SBOHF. O . . O . )FBEDJSDVNGFSFODF NFBOJODN TE SBOHF. O ¬. O . ¬. .BMFHFOEFS. . . 4("*1BOE1 4("1. . . . 5XJO. . . *OCPSO. . . "QHBSTDPSFTBUNJOVUFT NFBO TE. NFEJBO SBOHF. O . . O . . $3*#4DPSF NFEJBO SBOHF. 3%4* HSBEF HSBEF HSBEF HSBEF 4VSGBDUBOU )ZQFSCJMJSVCJOFNJB %BZTPGQIPUPUIFSBQZ NFBO TE. O ¬. O ¬. . . . . . . . . . . . . . %BUBTIPXOJTO VOMFTTPUIFSXJTFJOEJDBUFE $PNQBSJTPOTXFSFEPOFVTJOHDIJTRVBSFUFTU GPSMJOFBSUSFOE PSUUFTUTXIFSFBQQSPQSJBUF *4("TNBMMGPSHFTUBUJPOBMBHF 3%4SFTQJSBUPSZEJTUSFTTTZOESPNF. .

(12) $IBQUFS. 4FWFOUZUISFF JOGBOUT JO UIF /*%$"1 HSPVQ BOE JOGBOUTJOUIF$HSPVQSFRVJSFETPNFGPSNPGSFTQJSBUPSZTVQQPSU5IJTBOBMZTJTXBT CBTFEPOBMMJODMVEFEJOGBOUT8FQFSGPSNFEUIFTBNFBOBMZTJTPGUIFJOGBOUTXIP TVSWJWFE /*%$"1 $ 5IFJOGBOUDIBSBDUFSJTUJDTBTXFMM BTUIFQSJNBSZBOETFDPOEBSZPVUDPNFTTIPXFEOPTJHOJ¹DBOUEJGGFSFODFTCFUXFFO HSPVQT EBUBOPUTIPXO "MMPGUIFTVSWJWJOHJOGBOUT /*%$"1 $ XFSFBTTFTTFEBUUFSNBHF "HFBUGPMMPXVQBTTFTTNFOUXBTDPNQBSBCMFGPSCPUIHSPVQT5IFSFXBTOPTJH OJ¹DBOUEJGGFSFODFGPVOEJOUIFOFVSPMPHJDBMPVUDPNFTCFUXFFOUIF/*%$"1BOE$ HSPVQ5ISFFTVSWJWJOHJOGBOUT /*%$"1 $ EJBHOPTFEXJUIQPTUIFNPSSIBHJD WFOUSJDMFEJMBUBUJPOXFSFFYDMVEFEGSPNUIFXFFLMZBOEUFSNBHFIFBEDJSDVNGFS FODFBOBMZTJT5IFSFXBTOPTJHOJ¹DBOUEJGGFSFODFGPVOECFUXFFOUIF/*%$"1BOE $HSPVQJOUIFHSPXUIQBSBNFUFSTBUUFSNBHFPSJOEBJMZXFJHIUHBJO H XFFLMZ MFOHUIBOEIFBEDJSDVNGFSFODF DN HSPXUI 5BCMF " MJOFBS SFHSFTTJPO BOBMZTJT XBT DBSSJFE PVU UP BOBMZ[F JG UIF OVNCFS PG EBZT JOGBOUTSFDFJWFEUIF/*%$"1JOUFSWFOUJPOJOºVFODFEUIFOFVSPNPUPSPVUDPNFBOE HSPXUIBUUFSNBHFCZUFTUJOHJGUIFSFXBTBOJOUFSBDUJPOFGGFDUCFUXFFOUIFJOUFS WFOUJPOEVSBUJPOBOEUIFUXPUSFBUNFOUHSPVQT5IFSFXBTOPTJHOJ¹DBOUFGGFDUPO UIFOFVSPMPHJDBMPVUDPNF Q UFSNBHFIFBEDJSDVNGFSFODF Q UFSN BHFXFJHIU Q PSUFSNBHFMFOHUI Q GPVOE 4FDPOEBSZPVUDPNFT 5IF UPUBM MFOHUI PG TUBZ -04 GSPN CJSUI UP EJTDIBSHF UP IPNF PS UIF HFTUB UJPOBM BHF PG UIF JOGBOUT XIFO EJTDIBSHFE GSPN UIF IPTQJUBM XBT OPU EJGGFSFOU JO UIF HSPVQT 5IFSF XBT OP EJGGFSFODF JO UIF EBZT PG PYZHFO SFDFJWFE PS JOGBOUT UIBUSFRVJSFEPYZHFOBGUFSEBZTPSJODJEFODFPG#1%CFUXFFOUIFUXPHSPVQT*O UPUBM JOGBOUTJOUIF/*%$"1HSPVQSFRVJSFEQPTUOBUBMDPSUJDPTUFSPJET BTPQQPTFEUP JOGBOUTJOUIF$HSPVQ Q XJUIUXJDFBTNBOZ JOGBOUTJOUIF$HSPVQSFRVJSJOHDPSUJDPTUFSPJETGPSNPSFUIBOXFFLT5IFSFXFSF TJHOJ¹DBOUMZNPSFJOGBOUTJOUIF/*%$"1HSPVQ XJUI1%"SFRVJSJOH NFEJDBUJPOBOEPSTVSHFSZUIBOJOUIF$HSPVQ 0GUIF/*%$"1 JOGBOUTXJUI1%" EJFEJOIPTQJUBMBOE JOGBOUXJUI1%"EJFE JOUIF$HSPVQ8IFOXFBOBMZ[FEUIFTVSWJWJOHJOGBOUT UIF/*%$"1HSPVQ TUJMMIBEUXJDFBTNBOZJOGBOUTXJUI1%"UIBOUIF$HSPVQ Q"UUFSNBHFUIFSFXBTOPEJGGFSFODFJOUIFJODJEFODFPG17-PSUIFOVNCFS PG JOGBOUT SFRVJSJOH QIZTJDBM UIFSBQZ 5IFSF XFSF BMTP OP TJHOJ¹DBOU EJGGFSFODFT GPVOEJOUIFSFNBJOJOHTFDPOEBSZPVUDPNFT 5BCMF . .

(13) "3BOEPNJ[FE$POUSPMMFE5SJBMFYBNJOJOHUIF&GGFDUTPG/*%$"1. 5BCMF$PNQBSJTPOPGEBUBPGQSJNBSZPVUDPNFNFBTVSFT /*%$"1 O. $ O. %BZTPGIPTQJUBMJ[BUJPO NFBO TE. NFEJBO SBOHF. * . . . . . %BZT*$ NFBO TE. NFEJBO SBOHF. . . . . . /VNCFSPGJOGBOUTSFRVJSJOHSFTQJSBUPSZTVQQPSU %BZTPGNFDIBOJDBMWFOUJMBUJPO** NFBO TE. NFEJBO SBOHF. %BZTPG$1"1 NFBO TE. NFEJBO SBOHF. 5PUBMEBZTWFOUJMBUPSZTVQQPSU NFBO TE. NFEJBO SBOHF. . . . . . . . . . . . . . . . . (SPXUIQBSBNFUFSTBUUFSNBHF "HFJOXFFLT NFBO TE. 8FJHIUJOLH NFBO TE EBJMZXFJHIUHBJOJOHSBNT NFBO TE. )FBEDJSDVNGFSFODFJODN» NFBO TE XFFLMZIFBEDJSDVNGFSFODFHSPXUIJODN -FOHUIJODN NFBO TE XFFLMZHSPXUIJOMFOHUIJODN NFBO TE. O . O . . O . . O . . O . O . . O . . O . . /FVSPMPHJDBMPVUDPNFBUUFSN 1SFDIUM. OPSNBM NJMEMZBCOPSNBM EF¹OJUFMZBCOPSNBM. O . . . O . . . QWBMVF. . . %BUBTIPXOJTO VOMFTTPUIFSXJTFJOEJDBUFE $PNQBSJTPOTXFSFEPOFVTJOHDIJTRVBSFUFTU GPSMJOFBSUSFOE UUFTUTPS.BOO8IJUOFZUFTUTXIFSFBQQSP QSJBUF * BMTPJOEJDBUFTOVNCFSPGEBZTJOUFSWFOUJPOXBTHJWFO ** 4*.7BOEPS)'0 5PUBMEBZT4*.7 )'0BOE$1"1DPNCJOFE » *OGBOUTXJUIQPTUIFNPSSIBHJDWFOUSJDMFEJMBUBUJPO O/*%$"1 O$ XFSFFYDMVEFEGSPNIFBEDJSDVN GFSFODFBOBMZTJT 5XPJOGBOUTOPUBTTFTTFEBDDPSEJOHUP1SFDIUM. .

(14) $IBQUFS. 5BCMF$PNQBSJTPOPGEBUBPGTFDPOEBSZPVUDPNFNFBTVSFT /*%$"1 O. $ O. *OIPTQJUBMNPSUBMJUZ FBSMZOFPOBUBMEFBUI MBUFOFPOBUBMEFBUI. . . . . . . -04JOEBZT NFBO TE. NFEJBO SBOHF. O . . O . . . ("BUEJTDIBSHFUPIPNF NFBOJOXFFLT TE. O . O . . 5PUBMEBZTTVQQMFNFOUBM0 NFBO TE. NFEJBO SBOHF. 0SFRVJSFNFOUEBZTPGMJGF #1%. . . . . . . . 1PTUOBUBMDPSUJDPTUFSPJET EBZT EBZT EBZT EBZT. . . . . . . . . . *7) HSBEF*** HSBEF*** BOEQFSJWFOUSJDVMBSFDIPEFOTJUZ. 1PTUIFNPSSIBHJDWFOUSJDVMBSEJMBUBUJPO. . . . . . . . /&$ 4FQTJT .FOJOHJUJT 1%" JOEPNFUIBDJOBOEPSTVSHFSZ. %PQBNJOF%PCVUBNJOF 301. . . . . . . . . . . . . * . 17-BUUFSNBHFGPMMPXVQ HSBEF HSBEF HSBEF HSBEF 1IZTJDBMUIFSBQZSFRVJSFEBUUFSN. . . . . . . . . . QWBMVF. . . . %BUBTIPXOJTO VOMFTTPUIFSXJTFJOEJDBUFE $PNQBSJTPOTXFSFEPOFVTJOHDIJTRVBSFUFTU GPSMJOFBSUSFOE PSUUFTUTXIFSFBQQSPQSJBUF *QWBMVFXBTDPOTJEFSFETJHOJ¹DBOU -04MFOHUIPGTUBZ #1%CSPODIPQVMNPOBSZEZTQMBTJB *7)JOUSBWFOUSJDVMBSIBFNPSSIBHF /&$OFDSPUJTJOHFOUFSPDPMJUJT 1%"QBUFOUEVDUVTBSUFSJPTVT 301SFUJOPQBUIZPGQSFNBUVSJUZ 17-QFSJWFOUSJDVMBSMFVLPNBMBDJB. .

(15) "3BOEPNJ[FE$POUSPMMFE5SJBMFYBNJOJOHUIF&GGFDUTPG/*%$"1. 4VSWJWPS"OBMZTJT #FDBVTFPVSQSJNBSZPVUDPNFTXFSFSFTQJSBUPSZTVQQPSUBOE*$EBZT XFBMTP XBOUFEUPJODMVEFUIFEBUBGSPNUIFJOGBOUTXIPEJFEJOIPTQJUBM TPXFDBSSJFEPVU B,BQMBO.FJFSBOBMZTJT/PEJGGFSFODFTXFSFGPVOEJOUIFUPUBMQPQVMBUJPO 'JHVSFT BD #FDBVTFUIFSFXBTBTJHOJ¹DBOUEJGGFSFODFJOJODJEFODFPG1%"CFUXFFOUIF HSPVQT 5BCMF XFBMTPDBSSJFEPVUBQPTUIPD,BQMBO.FJFSTVSWJWBMBOBMZTJTBOE TUSBUJ¹FEGPSJOGBOUTXJUI1%"SFRVJSJOHNFEJDBUJPOPSTVSHFSZ PSJOGBOUTXJUIPVU TJHOJ¹DBOU 1%" *O UIF TVCHSPVQ PG JOGBOUT XJUI OP 1%" UIF /*%$"1 HSPVQ SFRVJSFE MFTT NFEJBO EBZT PG $1"1 Q UPUBM SFTQJSBUPSZ TVQQPSU Q BOEUPUBMEBZTJOUFOTJWFDBSF Q BTDPNQBSFEUPUIF$HSPVQ 'JHVSFTBC "T QIPUPUIFSBQZ NBZ JOºVFODF UIF DMPTVSF BOEPS SFPQFOJOH PG B 1%" XF DPNQBSFE EBZT PG QIPUPUIFSBQZ CVU GPVOE OP EJGGFSFODF CFUXFFO UIF HSPVQT /*%$"1NFBOEBZT $NFBOEBZT . %JTDVTTJPO *OUIJTSBOEPNJ[FEDPOUSPMMFEUSJBMFYBNJOJOHUIFTIPSUUFSNFGGFDUTPGUIFDPN QSFIFOTJWF/*%$"1EFWFMPQNFOUBMDBSFQSPHSBNDPNQBSFEUPCBTJDEFWFMPQNFO UBMDBSFPOOFPOBUBMNPSCJEJUZ OFVSPMPHJDBMPVUDPNFBOEHSPXUIBUUFSNBHFPG JOGBOUTCPSOXFFLT XFGPVOEOPTJHOJ¹DBOUQPTJUJWFFGGFDUTPGUIFJOUFSWFOUJPO POOFFEGPSSFTQJSBUPSZTVQQPSUPS*$EBZT5IFSFXFSFOPEJGGFSFODFTCFUXFFOUIF /*%$"1BOE$HSPVQJOHSPXUIBOEOFVSPMPHJDBMPVUDPNFTBUUFSNBHF FWFOXIFO DPSSFDUJOHGPSEBZTPGJOUFSWFOUJPO 3FTQJSBUPSZ4VQQPSU " $PDISBOF SFWJFX NFUBBOBMZTJT GPVOE JOGBOUT SFDFJWJOH /*%$"1 IBE TJHOJ¹ DBOUMZGFXFSWFOUJMBUJPOEBZTBOEOPEJGGFSFODFTJOEBZTPGPYZHFO IPXFWFSTUBUFE UIBUUIFSFTVMUTXFSFDPOºJDUJOHBOEUIFTUVEJFTTIPXFENVDIIFUFSPHFOFJUZBOE TIPVMECFSFWJFXFEXJUIDBVUJPO"O3$5CZ8FTUSVQFUBMPGJOGBOUTCPSOXJUI BHFTUBUJPOBMBHFXFFLTBOEXJUIUIFOFFEGPSWFOUJMBUPSZTVQQPSUBUIPVST TIPXFE OP TJHOJ¹DBOU EJGGFSFODF JO EBZT PG NFDIBOJDBM WFOUJMBUJPO BOE B USFOE Q JOEBZTPG$1"1JOGBWPSPGUIF/*%$"1HSPVQ /*%$"1 $ BTXFMMBTBZPVOHFS1$"PGPYZHFOXJUIESBXBM5IFOVNCFSPGJODMVEFEQBUJFOUT JOUIJTTUVEZXBTTNBMM & $ CFDBVTFUIFUSJBMIBEUPCFUFSNJOBUFEFBSMJFS UIBOFYQFDUFE &BSMJFS /*%$"1 TUVEJFT CZ "MT BOE 'MFJTDIFS IBWF BMTP TIPXO QPTJUJWF SFTVMUT DPODFSOJOH UIF OFFE GPS WFOUJMBUPSZ TVQQPSU IPXFWFS POMZ JOGBOUT CPSO ("BOECJSUIXFJHIUHSBNTXFSFJODMVEFEBOEUIFZIBETQFDJ¹DWFOUJMBUJPO. .

(16) $IBQUFS. 'JHVSFTBD$PNQBSJTPOPGEBZT$1"1 WFOUJMBUPSZTVQQPSUBOE*$EBZTPGBMMQBSUJDJQBUJOHJOGBOUT. Kaplan Meier analysis Control/Intervention group Control Intervention Control-censored Interventioncensored. 100. Percentage. 80. 60. 40. 20. 0 0. 10. 20. 30. 40. 50. 60. 70. Total days CPAP 5PUBMEBZT$1"1 Kaplan Meier analysis Control/Intervention group Control Intervention Control-censored Interventioncensored. 100. Percentage. 80. 60. 40. 20. 0 0. 20. 40. 60. 80. Total days respiratory support 5PUBMEBZTSFTQJSBUPSZTVQQPSU Kaplan Meier analysis Control/Intervention group Control Intervention Control-censored Interventioncensored. 100. Percentage. 80. 60. 40. 20. 0 0. 20. 40. 5PUBMEBZT*$ Total days IC . 60. 80.

(17) "3BOEPNJ[FE$POUSPMMFE5SJBMFYBNJOJOHUIF&GGFDUTPG/*%$"1. 'JHVSFB$PNQBSJTPOPGEBZTPGSFTQJSBUPSZTVQQPSUJOJOGBOUTXJUIOP1%". Kaplan Meier analysis. no PDA or PDA with no treatment Control/Intervention group Control Intervention Control-censored Interventioncensored. 100. Percentage. 80. 60. 40. 20. 0 0. 10. 20. 30. 40. 50. 60. 5PUBMEBZTSFTQJSBUPSZTVQQPSU Total days respiratory support. 'JHVSFC$PNQBSJTPOPGEBZTPGSFTQJSBUPSZTVQQPSUJOJOGBOUTXJUI1%" Kaplan Meier analysis. PDA treated with indocid and/or surgery Control/Intervention group Control Intervention Control-censored Interventioncensored. 100. Percentage. 80. 60. 40. 20. 0 0. 20. 40. 60. 80. 5PUBMEBZTSFTQJSBUPSZTVQQPSU Total days respiratory support. .

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