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VU Research Portal

Imaging P-glycoprotein: The gatekeeper of the blood-brain barrier

Raaphorst, R.M.

2019

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Raaphorst, R. M. (2019). Imaging P-glycoprotein: The gatekeeper of the blood-brain barrier: Development of

novel fluorine-18 labeled positron emission tomography tracers to investigate P-glycoprotein at the blood-brain

barrier.

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Table of Contents

Chapter 1

Introduction

Chapter 2

Radiopharmaceuticals for Assessing ABC Transporters at

the Blood-Brain Barrier

Chapter 3

Synthesis and Evaluation of New Fluorine-18 Labeled

Verapamil Analogs to Investigate the Function of

P-glycoprotein in the Blood-brain Barrier

Chapter 4

Improving Metabolic Stability of Fluorine-18 Labeled

Verapamil Analogs

Chapter 5

Comparison of In Vitro Assays in Selecting Radiotracers for

In Vivo P-Glycoprotein PET Imaging

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