University of Groningen
Integrative omics to understand human immune variation
Aguirre Gamboa, Raul
DOI:
10.33612/diss.98324185
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Aguirre Gamboa, R. (2019). Integrative omics to understand human immune variation. University of Groningen. https://doi.org/10.33612/diss.98324185
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
1
Integrative omics to understand
human immune variation
First printing, 2019
Printed by: Ipskamp Printing
Cover and Editorial design by: Anddy Ramos
Printng of this thesis was fnancially supported by: University of Groningen, University. Medical Center Groningen, the Groningen University Insttute for Drug Exploraton (GUIDE) and the Graduate School for Medical Sciences (GSMS), Groningen.
ISBN: 978-94-034-2090-5 (printed book) ISBN: 978-94-034-2089-9 (e-book)
Copyright (C) 2019 by Raúl Aguirre-Gamboa. All rights reserved. No part of this thesis may be reproduced, stored in a retrieved system, or transmitted in any form or by any means, without prior written permission from the author or from the publisher holding the copyright of the published articles.
-Raúl
3
Integrative omics to understand
human immune variation
Phd thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 14 October 2019 at 9.00 hours
by
Raúl Alejandro Aguirre Gamboa
born on 29 August 19864
Supervisors
Prof. C. Wijmenga Prof. Y. LiAssessment Committee
Prof. G.H. Koppelman Prof. A.L.W. Huckriede Prof. C. Tack5 Paranymphs
Lê Thị Thiên Kiều Adriaan van der Graaf
6 Chapter 1 Section 1 Chapter 2 Chapter 3 Chapter 4 Section 2 008 026 028 078 122 178 General introduction and aim and
outline of thesis.
Characterizing the inter-individual variation of the human immune system. Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits.
Cell Rep. 2016 Nov 22;17(9):2474-2487. A Functional Genomics Approach to Un-derstand Variation in Cytokine Production in Humans.
Cell. 2016 Nov 3;167(4):1099-1110.e14. Integration of multi-omics data and deep phenotyping enables prediction of cyto-kine responses.
Nat Immunol. 2018 Jul;19(7):776-786. The role of the transcriptome in immune cell types.
7 180 242 288 319 Chapter 5 Chapter 6 Chapter 7 Appendices
Deconvolution of bulk blood eQTL effects into immune cell subpopulations. In revision and in preprint
(DOI:10.1101/548669)
Dynamic and distinct transcriptional re-sponse of CD8+
Intraepithelial cytotoxic T lymphocytes to tissue alarmins and adaptive cytokines. In revision, Cell Reports.
Discussion and perspectives.
Summary. Sammenvatting. Resumen.
Acknowledgements. Curriculum Vitae.
