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University of Groningen

Bacterial interactions with nanostructured surfaces

Hizal, Ferdi

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Hizal, F. (2017). Bacterial interactions with nanostructured surfaces. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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BACTERIAL INTERACTIONS WITH

NANOSTRUCTURED SURFACES

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Bacterial interactions with nanostructured surfaces

By Ferdi Hizal

University Medical Center Groningen, University of Groningen Groningen, The Netherlands

Cover designed by Fermet Hizal Copyright © 2017 by Ferdi Hizal

Printed by Off Page, Amsterdam, The Netherlands

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BACTERIAL INTERACTIONS WITH

NANOSTRUCTURED SURFACES

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus, prof. dr. E. Sterken,

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

7 juni 2017 om 14:30 uur

door

Ferdi Hizal

geboren op 10 juni 1984

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P R O M O T O R E S

Prof. dr. ir. H.J. Busscher Prof. dr. H.C. van der Mei Prof. dr. C.-H. Choi

B E O O R D E L I N G S C O M M I S S I E

Prof. dr. Y. Ren

Prof. dr. ir. G.J. Verkerke Prof. dr. M.R. Libera

P A R A N I M F E N

Colin Rosman Yuri Ong

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T A B L E O F C O N T E N T S

Chapter 1 General Introduction: Current Developments in Bacterial Interactions with Nanostructured Surfaces

7

Aim of this Thesis 12

Chapter 2 Nanoengineered Superhydrophobic Surfaces of Aluminum with Extremely Low Bacterial Adhesivity

17

Chapter 3 Staphylococcal Adhesion, Detachment and Transmission on Nanopillared Si Surfaces

43

Chapter 4 Transmission of Staphylococcus epidermidis Biofilms from Smooth to Nanopillared Surfaces

65

Chapter 5 Impact of 3D Hierarchical Nanostructures on the Antibacterial Efficacy of a Bacteria-Triggered Self-Defensive Antibiotic Coating

81

Chapter 6 General Discussion 103

Summary 111

Samenvatting 114

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