University of Groningen
Mimicking heart disease in a dish Kijlstra, Jan David
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Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Kijlstra, J. D. (2018). Mimicking heart disease in a dish: Cardiac disease modelling through functional analysis of human stem cell derived cardiomyocytes. Rijksuniversiteit Groningen.
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Stellingen
Behorende bij het proefschrift:
Mimicking Heart Disease in a Dish
Cardiac Disease Modelling through Functional Analysis of Human Stem Cell Derived Cardiomyocytes
1. “The BASiC approach, yielding standard outputs of cardiomyocyte
contractile function such as fractional shortening and force generation, can be applied to human stem cell derived cardiomyocytes, unlike existing technologies geared towards adult murine cardiomyocytes.” - This thesis 2. “Integrated analysis of cardiomyocyte function such as simultaneous analysis
of contractile function and electrophysiology enhances the detection of aberrant cardiomyocyte function.” - This thesis
3. “The use of polyvinyl alcohol films as an intermediary allows for the
micropatterning of cardiomyocytes on a substrate that is flexible enough to allow them to contract.” – This thesis
4. “Microcontact printing of cardiomyocytes on a flexible substrate greatly improves the amount of contractile anisotropic cardiac cells available for functional analysis.” – This thesis
5. “Cardiomyocyte iron deficiency results in reduced activity of Fe-S cluster-based complexes in the mitochondria and ultimately reduced contractility, which is partly reversed upon iron supplementation.” – This thesis
6. “Repeated exposure of cardiomyocytes to low dose doxorubicin induces severe mitochondrial and contractile dysfunction, which unlike cell death might play pivotal roles in causing doxorubicin induced cardiomyopathy.” – This thesis
7. “A thorough recognition of the key differences between immature human stem cell derived cardiomyocytes in vitro and the mature cardiomyocytes in patients’ hearts is crucial for efficient translation of new insights from bench to bedside.” - This thesis
8. “I didn't fail the test, I just found 100 ways to do it wrong.” - Benjamin Franklin
9. “The reasonable man adapts himself to the world: the unreasonable one persists in trying to adapt the world to himself. Therefore all
progress depends on the unreasonable man.” – George Bernard Shaw 10. “I don't know where I'm going, but I promise it won't be boring.” - David
