University of Groningen
MicroRNA expression and functional analysis in Hodgkin lymphoma
Yuan, Ye
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Publication date: 2019
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Yuan, Y. (2019). MicroRNA expression and functional analysis in Hodgkin lymphoma. University of Groningen.
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MicroRNA expression and functional
analysis in Hodgkin lymphoma
ISBN (printed): 978-94-034-1397-6
ISBN (digital): 978-94-034-1396-9
The studies described in this thesis were financially supported by:
Graduate School of medical university
Publication of this thesis was financially supported by:
University of Groningen
Graduate School of medical university
MicroRNA expression and functional analysis in Hodgkin lymphoma
©copyright 2019 Ye Yuan
All rights reserved.
MicroRNA expression and
functional analysis in Hodgkin
lymphoma
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 13 February 2019 at 12.45 hours
by
ISBN (printed): 978-94-034-1397-6
ISBN (digital): 978-94-034-1396-9
The studies described in this thesis were financially supported by:
Graduate School of medical university
Publication of this thesis was financially supported by:
University of Groningen
Graduate School of medical university
MicroRNA expression and functional analysis in Hodgkin lymphoma
©copyright 2019 Ye Yuan
All rights reserved.
Cover design: Ye Yuan
Layout: Ye Yuan
Printed by: Gildeprint
MicroRNA expression and
functional analysis in Hodgkin
lymphoma
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 13 February 2019 at 12.45 hours
by
Ye Yuan
born on 25 September 1987 in Heilongjiang, China
Supervisor
Prof. J.H.M. van den Berg
Co-supervisor
Dr. J.L. KluiverAssessment Committee
Prof. G. de Haan Prof. E. Vellenga Prof. D. de JongSupervisor
Prof. J.H.M. van den Berg
Co-supervisor
Dr. J.L. KluiverAssessment Committee
Prof. G. de Haan Prof. E. Vellenga Prof. D. de JongParanymphs
Fubiao Niu Wangzhao Song
Contents
Chapter 1 Introduction and scope of the thesis
Chapter 2 MicroRNA-24-3p is overexpressed in Hodgkin lymphoma and protects
Hodgkin and Reed-Sternberg cells from apoptosis
The American Journal of Pathology, February 16, 2017
Chapter 3 Setting up a high throughput screen in Hodgkin lymphoma
Part A Feasibility testing of high-throughput screen in Hodgkin lymphoma cell lines using an empty vector barcoded approach
Part B A pilot high-throughput screen to elucidate the role of microRNAs in Hodgkin lymphoma cell growth
Chapter 4 High-throughput microRNA gain-of-function screening in Hodgkin
lymphoma Work in progress
Chapter 5 MicroRNA high throughput loss-of-function screening reveals an
oncogenic role for miR-21-5p in Hodgkin lymphoma
Cellular Physiology and Biochemistry, Epub September 5, 2018
Chapter 6 Summary, discussion and future perspectives Appendix Nederlandse samenvatting
Publications Acknowledgements Biography
Paranymphs
Fubiao Niu Wangzhao Song
Contents
Chapter 1 Introduction and scope of the thesis
Chapter 2 MicroRNA-24-3p is overexpressed in Hodgkin lymphoma and protects
Hodgkin and Reed-Sternberg cells from apoptosis
The American Journal of Pathology, February 16, 2017
Chapter 3 Setting up a high throughput screen in Hodgkin lymphoma
Part A Feasibility testing of high-throughput screen in Hodgkin lymphoma cell lines using an empty vector barcoded approach
Part B A pilot high-throughput screen to elucidate the role of microRNAs in Hodgkin lymphoma cell growth
Chapter 4 High-throughput microRNA gain-of-function screening in Hodgkin
lymphoma Work in progress
Chapter 5 MicroRNA high throughput loss-of-function screening reveals an
oncogenic role for miR-21-5p in Hodgkin lymphoma
Cellular Physiology and Biochemistry, Epub September 5, 2018
Chapter 6 Summary, discussion and future perspectives Appendix Nederlandse samenvatting
Publications Acknowledgements Biography 9 21 53 55 77 97 121 151 173 179 181 185
