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Exciting circuits
Deep brain stimulation for depression
Bergfeld, I.O.
Publication date
2018
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Citation for published version (APA):
Bergfeld, I. O. (2018). Exciting circuits: Deep brain stimulation for depression.
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Exciting circuits
Deep brain stimulation
for depression
Isidoor Bergfeld
Exciting circuits
EXCITING CIRCUITS
The studies described in this thesis were performed at the Department of Psychiatry of the Academic Medical Center, Amsterdam, The Netherlands. Cover lay-out: Isidoor Bergfeld
Icons on the cover are downloaded from flaticons.com and are used with per-mission. They are designed by Freekpik (Light bulb brain, Football, Guitar player, Text lines, Seahorse, Brainstorm, Gramophone, Footprint, Houses, Farm, Bungee jumping), Those Icons (Angry, Bored, In love, Sad, Smile, and Stress emoticons), Smashicons (Monkey, Battery, Handshake), Eucalyp (Brain surgery, Hand with growth sign), Turkkub (Eye, Lungs), Nikita Gol-ubev (Cards), Good Ware (Heart), Wissawa Khamsriwath (Beer), Monkik (Ear), and mynamepong (Hand brake).
Printed by: Print Service Ede (proefschriftprinten.nl) ISBN: 978-94-92679-46-8
There must be some kinda way out of here...
Bob Dylan, as adapted by Jimi Hendrix
EXCITING CIRCUITS Deep brain stimulation for depression
ACADEMISCH PROEFSCHRIFT ter verkrijging van de graad van doctor
aan de Universiteit van Amsterdam op gezag van de Rector Magnificus
prof. dr. ir. K.I.J. Maex
ten overstaan van een door het College voor Promoties ingestelde commissie, in het openbaar te verdedigen in de Agnietenkapel
op vrijdag 6 juli 2018, te 12:00 uur door Isidoor Otto Bergfeld
Promotiecommissie:
Promotores Prof. dr. D.A.J.P. Denys AMC-UvA
Prof. dr. P.R. Schuurman AMC-UvA
Copromotor Dr. M.H.M. Mantione UMC Utrecht
Overige leden Prof. dr. T.E. Schlaepfer University of Freiburg
Prof. dr. W. Cahn Universiteit Utrecht
Prof. dr. C.L.H. Bockting AMC-UvA
Dr. G.J. Geurtsen AMC-UvA
Dr. A. Lok AMC-UvA
Contents
I
General introduction
11
1 Introduction 13
II
Efficacy of deep brain stimulation
17
2 Deep brain stimulation of the ventral anterior limb of the
internal capsule for treatment-resistant depression - A
ran-domized clinical trial 19
3 Inaccurate psychiatric diagnosis leads to unnecessary
func-tional neurosurgery 43
III
Safety of deep brain stimulation
47
4 Treatment-resistant depression and suicidality 49
5 Cognitive functioning following deep brain stimulation in
psy-chiatric disorders 59
6 The impact of deep brain stimulation of the verntral anterior
limb of the internal capsule on cognition in depression 73
7 Episodic memory following deep brain stimulation of the
ven-tral anterior limb of the internal capsule and electroconvulsive
therapy 89
Table of contents
