University of Groningen

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University of Groningen

Melanoma Deckers, Eric

DOI:

10.33612/diss.121578427

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Deckers, E. (2020). Melanoma: the Impact of Staging on Treatment, Prognosis & Follow-up. University of Groningen. https://doi.org/10.33612/diss.121578427

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Download date: 24-06-2021

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University of Groningen

Melanoma Deckers, Eric

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Deckers, E. (2020). Melanoma: the Impact of Staging on Treatment, Prognosis & Follow-up. [Groningen]:

University of Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

Download date: 15-04-2020

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541959-L-bw-Deckers 541959-L-bw-Deckers 541959-L-bw-Deckers 541959-L-bw-Deckers Processed on: 24-3-2020 Processed on: 24-3-2020 Processed on: 24-3-2020

Processed on: 24-3-2020 PDF page: 1PDF page: 1PDF page: 1PDF page: 1

Melanoma

The impact of staging on treatment, prognosis & follow-up

E.A. Deckers

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Colofon

Layout & cover design FYN Werk, grafische vormgeving

www.fynwerk.nl Printed by

Gildeprint Drukkerijen, Enschede www.gildeprint.nl Cover illustration

Iiulia White

Sponsoring

The research described in this thesis was supported by a research grant from the Groningen Melanoma Sarcoma Foundation.

The printing of this thesis was kindly supported by:

University Medical Center Groningen (UMCG);

Graduate School of Medical Sciences Groningen;

Noord Negentig, accountants en belastingadviseurs;

ChipSoft.

ISBN: 978-94-6402-178-3 (book) ISBN: 978-94-6402-203-2 (e-book)

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Melanoma

The impact of staging on treatment, prognosis & follow-up

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op maandag 26 oktober 2020 om 14.30 uur

door

Eric Arnoud Deckers geboren op 06 maart 1989

te Nieuwegein

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Promotor

Prof. dr. H.J. Hoekstra Copromotores

Dr. J.E.H.M. Hoekstra-Weebers Dr. S. Kruijff

Beoordelingscommissie Prof. dr. H.B.M. van de Wiel Prof. dr. G.A.P. Hospers Prof. dr. R.A.E.M. Tollenaar

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Paranimfen

Rob de Vries

Thomas Zwols

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1

General introduction 9

2A

The MELFO-Study: a multi-center prospective randomized clinical trial on the effects of a reduced stage-adjusted follow-up schedule on cutaneous melanoma IB-IIC patients

- results after 3-years 25

2B

ASO author reflections: Stage-adjusted reduced follow-up of melanoma patients is justified and cost effective, until

biomarkers to predict prognosis have been identified 45

3

Increase of sentinel lymph node melanoma staging in the

Netherlands; still room and need for further improvement 51

4

Obesity is not associated with decreased recurrence-free period, melanoma-specific survival, and overall survival in

clinical stage IB-II melanoma patients 73

5

S-100B as an extra selection tool for FDG PET/CT scanning

in follow-up of AJCC Stage III melanoma patients 97

6

The association between active tumor volume, total lesion glycolysis and levels of S-100B and LDH in stage IV melanoma

patients 115

7

Summary and conclusion 139

8

Samenvatting en conclusie 149

9

Future perspectives 159

10

Curriculum vitae 179

Dankwoord 183

Tabel of contents

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8