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Cover Page

The handle

http://hdl.handle.net/1887/138131

holds various files of this Leiden

University dissertation.

Author:

Yang, W.

Title:

Cryo electron tomography studies of bacterial chemosensory arrays

Issue Date:

2020-11-04

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Cryo Electron Tomography Studies of

Bacterial Chemosensory Arrays

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PhD Thesis, Leiden University, 2020. Cover design and layout by Wen Yang Printed by Ridderprint | www.ridderprint.nl

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Cryo Electron Tomography Studies of

Bacterial Chemosensory Arrays

Proefschift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden,

op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties

te verdedigen op woensdag 4 November 2020

klokke 15.00 uur

door

Wen Yang

geboren te Fuzhou, China

in 1987

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Promotiecommisssie

Promotoren: Prof. dr. A. Briegel Prof. dr. G. P. van Wezel

Overige leden: Prof. dr. A. H. Meijer Prof. dr. H. P. Spaink Prof. dr. T. S. Shimizu Dr. T. H. Sharp Dr. S. I. van Kasteren

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Contents

Chapter 1 General Introduction

Chapter 2 Diversity of bacterial chemosensory arrays Chapter 3 Baseplate variability of chemosensory arrays in Vibrio cholerae

Chapter 4 Kinase distribution in Vibrio cholerae F6 chemotaxis arrays

Chapter 5 In situ conformational changes of the Escherichia coli serine chemoreceptor in different signaling states

Chapter 6 Use cryo electron tomography to study the structure of chemoreceptor arrays in situ

Chapter 7 General Discussion

Nederlandse Samenvatting References Curriculum Vitae Publications 6 16 32 54 66 88 100 110 114 134 135

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