University of Groningen
Morphologic analysis of the apicoplast formation in Plasmodium falciparum
Linzke, Marleen
DOI:
10.33612/diss.107482905
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Linzke, M. (2019). Morphologic analysis of the apicoplast formation in Plasmodium falciparum. University of
Groningen. https://doi.org/10.33612/diss.107482905
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Propositions
accompanying the thesisMORPHOLOGICAL ANALYSIS OF THE APICOPLAST
FORMATION IN PLASMODIUM FALCIPARUM
by
Marleen Linzke
1. Increasing resistance to antimalarial drugs hinders the eradication efforts for malaria (this thesis).
2. The apicoplast is an essential organelle of the Plasmodium parasite and its metabolic functions can be exploited as source for new drug targets (this thesis).
3. If Plasmodium has developed a new mechanism of correct organelle division or inherited the ancestry system is not solved yet (this thesis).
4. The protein interference assay (PIA) can be successfully used as method for drug target validation in Plasmodium (this thesis).
5. Each protein is different. While some are easy to handle, others need special care. It can be the smallest changes in the procedure that make the biggest difference for the protein (personal experience).
6. Mentalities and conditions can change from country to country. But somehow, if you really want it to happen, it can work wherever you are in the world (personal experience). 7. To plan in advance will help with the experiments. But to learn how to handle the frustration when the plan fails and start over again is the real secret to survive the PhD (personal experience).
8. “One of the beautiful things about science is that it allows us to bumble along, getting it wrong time after time, and feel perfectly fine as long as we learn something each time.” (The importance of stupidity in scientific research – Martin A. Schwartz)
9. “Zwei Dinge sind zu unserer Arbeit nötig: Unermüdliche Ausdauer und die Bereitschaft, etwas, in das man viel Zeit und Arbeit gesteckt hat, wieder wegzuwerfen.“ (Albert Einstein)
