Reversal of drug-affected breathing
Bijl, J.H.L.Citation
Bijl, J. H. L. (2006, June 21). Reversal of drug-affected breathing. Retrieved from https://hdl.handle.net/1887/4419
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4419
Reversal of Drug-Affected Breathing
Reversal of Drug-Affected Breathing
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de UniversiteitLeiden, op gezag van de Rector M agnificus Dr.D.D.Breimer,
hoogleraar in de faculteitder W iskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluitvan hetCollege voor Promoties
te verdedigen op woensdag 21 juni2006 te klokke 14.15 uur
door
Johan
Hai
ko
Leonard
Bi
j
l
Promotiecommissie
Promotor: Prof. Dr. A. Dahan Co-promotor: Dr. L.J.S.M. Teppema Referent: Prof. Dr. P.J. Sterk Overige leden: Prof. Dr. J.W. van Kleef
The investigations described in chapters 2–5 of this thesis were performed in the Anesthesia and Pain Research Unit, Department of Anesthesiology, Leiden University Medical Center, under the supervision of Prof. Dr. A. Dahan (part of the investigations in chapter 2 were performed in the Leiden/Amsterdam Center for Drug Research, Division of Pharmacology, Gorlaeus Laboratory, Leiden). The investigations described in chapters 6 and 7 of this thesis were performed in the Laboratory of Physiology, Department of Anesthesiology, Leiden University Medical Center, under the supervision of Dr. L.J.S.M. Teppema.
Copyright © 2006 by Johan H.L. Bijl
Except cover design © 2006 by Philip Hozier
Printed by PrintPartners Ipskamp, Enschede, The Netherlands ISBN-10: 90-9020693-0
ISBN-13: 978-90-9020693-6
Financial support for the printing of this thesis was provided by:
The Department of Anesthesiology, LUMC, Leiden, The Netherlands Abbott Nederland BV, Hoofddorp, The Netherlands
Schering-Plough BV, Utrecht, The Netherlands
ʊ CONTENTS ʊ
1 Introduction 9
Section 1 Ceiling and Naloxone-Reversal of Buprenorphine-Induced Respiratory Depression
2 Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats
British Journal of Anaesthesia 2005; 94: 825-34
21
3 Buprenorphine induces ceiling in respiratory depression but not in analgesia
British Journal of Anaesthesia 2006; 96: 627-32
35
4 Naloxone-reversal of opioid-induced respiratory depression with special emphasis on buprenorphine
Submitted
45
Section 2 Respiratory Effects of Carbonic Anhydrase Inhibitors and Antioxidants
5 Antioxidants reverse depression of the hypoxic ventilatory response by acetazolamide in man
Journal of Physiology (London) 2006; 572: 849-56
61
6 Effects of low-dose methazolamide on the control of breathing in cats
Advances in Experimental Medicine and Biology 2006; 580: 257-62
75
7 The carbonic anhydrase inhibitors methazolamide and
acetazolamide have different effects on the hypoxic ventilatory response in the anesthetized cat
Submitted
83
8 Summary and Conclusions ʊ Samenvatting en Conclusies 97
