University of Groningen
Hirschsprung's disease: early diagnosis and long-term outcomes
Meinds, Rob Jelle
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2019
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Meinds, R. J. (2019). Hirschsprung's disease: early diagnosis and long-term outcomes. Rijksuniversiteit
Groningen.
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Hirschsprung’s disease:
early diagnosis &
long-term outcomes
ISBN (print) 978-94-034-1042-5
ISBN (e-pub) 978-94-034-1041-8
Lay-out Rob J. Meinds
Cover art Vivian Jay
(EBB+FLOW watercolors)
Printed by PrintQuest, Deventer Publication of this thesis was financialy supported by the Junior Scientific Masterclass, the Graduate School of Medical Sciences, the University of Groningen, and the University Medical Center Groningen.
The research described in this thesis was performed within the Department of Pediatric Surgery and the Anorectal Physiology Laboratory of the University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
© 2019 R.J. Meinds
All rights reserved. No part of this thesis may be reproduced or transmitted, in any form or by any means, without permission of the author.
Hirschsprung’s disease: early diagnosis
and long-term outcomes
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 13 februari 2019 om 14.30 uur
door
Rob Jelle Meinds
geboren op 15 juli 1992 te Stadskanaal
Promotor Prof. dr. E. Heineman Copromotor Dr. P.M.A. Broens Beoordelingscommissie Prof. dr. U. Rolle Prof. dr. H.J. Verkade Prof. dr. R.K. Weersma
Paranimfen
Drs. S.L. Meinds Ir. T.G. Meinds
1
General introduction and aims 8PART I
Early diagnosis of Hirschsprung’s disease
2
Infant’s age influences the accuracy of rectal suction biopsies for diagnosing of Hirschsprung’s disease32
3
Anorectal manometry may reduce the number of rectal suction biopsyprocedures needed to diagnose Hirschsprung’s disease
50
4
Immaturity of the rectoanal inhibitory reflex as a cause of severeconstipation in newborns
68
5
Solitary rectal ulcer syndrome as a sign of unrecognized Hirschsprung’sdisease
82
PART II
Defecation disorders in the general population
6
Reproducibility, feasibility, and validity of the Groningen Defecation and Fecal Continence questionnaires92
7
On the prevalence of constipation and fecal incontinence, and theirco-occurrence, in the Netherlands
108
PART III
Long-term outcomes of Hirschsprung’s disease
8
Long-term functional outcomes and quality of life in patients with Hirschsprung’s disease128
9
Matched comparison of outcomes following Duhamel and transanalendorectal pull-through procedures in patients with Hirschsprung’s disease
146
10
Dyssynergic defecation may play an important role in postoperative Hirschsprung’s disease patients with severe persistent constipation164
11
General discussion and future perspectives 18012
Summary 19413
Samenvatting (Dutch summary) 202APPENDICES
The Groningen DeFeC questionnaire 212
Abbreviations 228
Dankwoord (acknowledgements) 229
About the author 232
