• No results found

Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands

N/A
N/A
Protected

Academic year: 2021

Share "Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands"

Copied!
3
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands

Weterings, J.J.

Citation

Weterings, J. J. (2008, November 27). Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands. Bio-organic Synthesis, Leiden Institute of Chemistry, Faculty of Science, Leiden University. Retrieved from https://hdl.handle.net/1887/13284

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13284

Note: To cite this publication please use the final published version (if applicable).

(2)

135

List of Publications

Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells.

Selina Khan, Jimmy J. Weterings, Cedrik M. Britten, Ana R. de Jong, Dirk Graafland, Cornelis J. Melief, Sjoerd H. van der Burg, Gijs van der Marel, Hermen S. Overkleeft, Dmitri Filippov and Ferry Ossendorp, Mol. Immunol., 2008, accepted.

Synthesis of modified and hybrid protein derived biopolymers.

Jimmy J. Weterings, Selina Khan, Jan W. Drijfhout, Ferry Ossendorp, Herman S. Overkleeft, Gijsbert A. van der Marel and Dmitri V. Filippov, Peptides for youth, 2007, American Peptide Society.

Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells.

S. Khan, M. S. Bijker, J. J. Weterings, H. J. Tanke, G. J. Adema, T. van Hall, J.W. Drijfhout, C. J. Melief, H. S. Overkleeft, G. A. van der Marel, D. V. Filippov, S. H. van der Burg, F.

Ossendorp, J. Biol. Chem., 2007, 282, 21145-59.

Synthesis of 2-alkoxy-8-hydroxyadenylpeptides: towards synthetic epitope-based vaccines.

J. J. Weterings, S. Khan, G. J. van der Heden, J. W. Drijfhout, C. J. Melief, H. S. Overkleeft, S. H. van der Burg, F. Ossendorp, G. A. van der Marel, D. V. Filippov, Bioorg. Med. Chem.

Lett., 2006, 16, 3258-61.

(3)

136

Synthesis of thiol-modified peptide nucleic acids designed for post-assembly conjugation reactions.

M. C. de Koning, L. Petersen, J. J. Weterings, M. Overhand, G. A. van der Marel, D. V.

Filippov, Tetrahedron, 62, 3248-3258.

Synthesis and in vitro evaluation of PNA-peptide-DETA conjugates as potential cell penetrating artificial ribonucleases.

L. Petersen, M. C. de Koning, P. van Kuik-Romeijn, J. Weterings, C. J. Pol, G. Platenburg, M. Overhand, G. A. van der Marel, J. H. van Boom, Bioconjugate Chem., 2004, 15, 576-82

Referenties

GERELATEERDE DOCUMENTEN

Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands.. Bio-organic Synthesis, Leiden Institute of Chemistry, Faculty of Science,

The aim of the studies described in this thesis is the preparation of well defined TLR2, TLR7 and TLR9 ligands either alone or linked to antigenic peptide. The synthetic

The solvent was evaporated and the residue was applied to column chromatography using a two step gradient; 25% toluene in EtOAc to 100% EtOAc to 5% MeOH in EtOAC yielding 104 mg

The assembly of conjugates 3, 4 and 5 (Figure 3.1) based on Huisgen [3+2] cycloaddition requires the availability of an azide-containing TLR7 agonist. Chronologically, compound 2

Further support of enhanced uptake mediated by the conjugates was provided from the here described in vivo uptake analysis, which revealed a 6–8-fold increase in uptake of

In this chapter, the effect of configuration at the C-2 position of the glycerol moiety of the Pam 3 CysSK 4 linked to OVA 247-264 antigenic peptide on maturation and activation

Although presentation of the antigenic peptide, SIINFEKL, proceeded more efficiently using these constructs compared to the separate TLR-L and peptide parts, TLR7 dependent cytokine

De resultaten besproken in Hoofdstuk 4 en 5 laten zien dat de opname, de TLR binding en de intracellulaire verwerking van deze conjugaten belangrijk zijn voor optimale cytokine