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Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands

Weterings, J.J.

Citation

Weterings, J. J. (2008, November 27). Synthesis and evaluation of peptide and nucleic acid based Toll-like receptor ligands. Bio-organic Synthesis, Leiden Institute of Chemistry, Faculty of Science, Leiden University. Retrieved from https://hdl.handle.net/1887/13284

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13284

Note: To cite this publication please use the final published version (if applicable).

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Table of Contents

List of abbreviations 5

Chapter 1

General Introduction 9

Chapter 2

7-Hydro-8-oxo-adenine derivatives as potent TLR7 ligands 35

Chapter 3

7-Hydro-8-oxo-adenine peptide conjugates via Huisgen Cycloaddition 57

Chapter 4

Toll-like Receptor Ligand-Peptide conjugates to study antigen processing 71 in Dendritic Cells

Chapter 5

Comparison of R-and S-configured glycerol containing triacylglycerollipids 107 in TLR-2 mediated immune response

Chapter 6

Summary and Future Prospects 123

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Table of Contents

Samenvatting 131

List of Publications 135

Curriculum Vitae 137

Nawoord 139

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