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The handle http://hdl.handle.net/1887/38587 holds various files of this Leiden University dissertation.
Author: Suurmond, Jolien
Title: Immune regulation by mast cells
Issue Date: 2016-03-22
IMMUNE REGULATION BY MAST CELLS
Jolien Suurmond
Immune regulation by mast cells Copyright © Jolien Suurmond, 2016
All rights are reserved. No part of this publication may be reproduced, stored, or transmitted in any form or by any means without permission of the copyright owners.
ISBN: 978-94-6299-286-3 Cover design: JacQ Creative.
Illustration: © Dr. Jastrow's electron microscopic atlas on http://www.drjastrow.de.
Reprinted with permission from Dr. H Jastrow.
Printing: Ridderprint BV, The Netherlands
The research described in this thesis was performed at the department of Rheumatology of the Leiden University Medical Center, Leiden, The Netherlands.
The work described in this thesis was funded by the Dutch Arthritis Foundation, whom we thank for their support. Additional financial support was obtained from the Dutch Organization for Scientific Research (Vici grant), the Research Foundation Sole Mio, the Leiden Research Foundation (STROL), the Centre for Medical Systems Biology (CMSB) within the framework of the Netherlands Genomics Initiative (NGI), the IMI JU funded project BeTheCure, contract no 115142-2, and European Union (Seventh Framework Programme integrated project Masterswitch; grant Number: 223404).
Printing of this thesis was financially supported by the Leiden University Medical Center, Leiden University, and BD Biosciences.
IMMUNE REGULATION BY MAST CELLS
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 22 maart 2016
klokke 16:15 uur
door
Jolien Suurmond
geboren te Gouda
in 1985
Promotores Prof.dr. R.E.M. Toes Prof.dr. T.W.J. Huizinga Promotiecommissie Prof.dr. P.S. Hiemstra
Prof.dr. B. Diamond, Feinstein Institute for Medical Research, NY, USA Prof.dr. M. Yazdanbakhsh
Dr. E.F. Knol, Universitair Medisch Centrum Utrecht Dr. M.W. Schilham
CONTENTS
Chapter 1 Introduction 7
Part I Combined innate and Fc receptor triggering of mast cells and basophils
Chapter 2 Activation of human basophils by combined toll-like receptor- and FcεRI triggering can promote Th2 skewing of naïve Thelper cells
37
Chapter 3 IgE and IL-33-mediated triggering of human basophils inhibits TLR4-induced monocyte activation
59
Chapter 4 Differential TLR-induced cytokine production by human mast cells is amplified by FcɛRI triggering
81
Chapter 5 Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies
95
Chapter 6 Ability of IL-33- and immune complex-triggered activation of human mast cells to down-regulate monocyte-mediated immune responses
115
Part II Interactions between mast cells and CD4+ T cells
Chapter 7 Communication between human mast cells and CD4+ T cells through antigen-dependent interactions
139
Chapter 8 Human mast cells co-stimulate T cells through a CD28- independent interaction
157
Chapter 9 Th17 expansion by human mast cells is driven by inflammasome- independent IL-1β
175
Part III Antibody-mediated chronic inflammation in allergy and autoimmunity
Chapter 10 Repeated FcεRI triggering reveals modified mast cell function related to chronic allergic responses in tissue
197
Chapter 11 Mast cells in rheumatic disease 233
Chapter 12 Autoantibodies in systemic autoimmune diseases: Specificity and pathogenicity
257
Chapter 13 Therapeutics to block autoantibody initiation and propagation in systemic lupus erythematosus and rheumatoid arthritis
277
Chapter 14 Summary and discussion 291
Chapter 15 Nederlandse samenvatting 323
Addendum
List of publications 333
Curriculum vitae 335
Dankwoord 337
