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University of Groningen

In search of animal models for male sexual dysfunction

Esquivel Franco, Diana

DOI:

10.33612/diss.95008507

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Esquivel Franco, D. (2019). In search of animal models for male sexual dysfunction: Pharmacological studies in normal and serotonin transporter knockout rats. Rijksuniversiteit Groningen.

https://doi.org/10.33612/diss.95008507

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In search of animal models

for sexual dysfunction

Pharmacological studies in normal and serotonin transporter knockout rats

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The Project presented in this thesis was a collaboration between the University of Groningen (RUG), The Netherlands, and Universidad Nacional Autónoma de México (UNAM), Mexico. The research was performed at the Behavioral Neurobiology group at the Groningen Institute for Evolutionary Life Sciences (GELIFES, RUG) and the Department of Cell Biology and Physiology at the Instituto de Investigaciones Biomédicas (IIB-UNAM). The study was supported by individual training provided by a Scholarship at the RUG and a CONACyT scholarship at the UNAM, Mexico.

The printing of this thesis was financially supported by the University of Groningen and the Graduate School of Science and Engineering (GSSE) of the Faculty of Science and Engineering.

Cover design and layout © evelienjagtman.com

Printed by Ridderprint BV | www.ridderprint.nl ISBN 978-94-034-1810-0 (printed version) ISBN 978-94-034-1811-7 (electronic version)

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In search of animal models for

male sexual dysfunction

Pharmacological studies in normal

and serotonin transporter knockout rats

PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. C. Wijmenga

and in accordance with the decision by the College of Deans

and

to obtain the degree of PhD at the Universidad Nacional Autónoma de México

on the authority of the Rector Magnificus Prof. E. Graue

and in accordance with the decision by the College of Deans.

Double PhD degree

This thesis will be defended in public on Friday 20 September 2019 at 14.30 hours

by

Diana Carolina Esquivel Franco

born on 28 August 1987 in Mexico City, Mexico

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Supervisors Prof. J.D.A. Olivier Prof. M.J.H. Kas

Prof. G. Gutierrez Ospina Assessment Committee Prof. A. Scheurink

Prof. J.C. Billeter Prof. L. Vanderschuren Prof. G. Roldan Roldan

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Para mi hermosa, pequeña y amada Agnes For my beloved Agnes Voor mijn kleine lieve Agnes

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Contents

Chapter 1 Introduction 9

Chapter 2 Is ejaculation latency related to the size of the genital cortical representation?

35

Chapter 3 Sexual behavior in male Serotonin Transporter Knockout rats 55 Chapter 4 Tramadol: effects on sexual behavior in male rats are mainly

caused by its 5-HT reuptake blocking effects

75

Chapter 5 Tramadol’s inhibitory effects on sexual behavior: pharmacological studies in serotonin transporter knockout rats

97

Chapter 6 Pharmacological studies on the role of 5-HT1A receptors in male sexual behavior of wildtype and serotonin transporter knockout rats

141

Chapter 7 General Discussion 183

Appendix References English Summary Nederlandse samenvatting Resumen en español Acknowledgments Biography List of publications Funding 195 213 223 233 243 249 253 257

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