University of Groningen
In search of animal models for male sexual dysfunction
Esquivel Franco, Diana
DOI:
10.33612/diss.95008507
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Esquivel Franco, D. (2019). In search of animal models for male sexual dysfunction: Pharmacological studies in normal and serotonin transporter knockout rats. Rijksuniversiteit Groningen.
https://doi.org/10.33612/diss.95008507
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In search of animal models
for sexual dysfunction
Pharmacological studies in normal and serotonin transporter knockout rats
The Project presented in this thesis was a collaboration between the University of Groningen (RUG), The Netherlands, and Universidad Nacional Autónoma de México (UNAM), Mexico. The research was performed at the Behavioral Neurobiology group at the Groningen Institute for Evolutionary Life Sciences (GELIFES, RUG) and the Department of Cell Biology and Physiology at the Instituto de Investigaciones Biomédicas (IIB-UNAM). The study was supported by individual training provided by a Scholarship at the RUG and a CONACyT scholarship at the UNAM, Mexico.
The printing of this thesis was financially supported by the University of Groningen and the Graduate School of Science and Engineering (GSSE) of the Faculty of Science and Engineering.
Cover design and layout © evelienjagtman.com
Printed by Ridderprint BV | www.ridderprint.nl ISBN 978-94-034-1810-0 (printed version) ISBN 978-94-034-1811-7 (electronic version)
In search of animal models for
male sexual dysfunction
Pharmacological studies in normal
and serotonin transporter knockout rats
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans
and
to obtain the degree of PhD at the Universidad Nacional Autónoma de México
on the authority of the Rector Magnificus Prof. E. Graue
and in accordance with the decision by the College of Deans.
Double PhD degree
This thesis will be defended in public on Friday 20 September 2019 at 14.30 hours
by
Diana Carolina Esquivel Franco
born on 28 August 1987 in Mexico City, Mexico
Supervisors Prof. J.D.A. Olivier Prof. M.J.H. Kas
Prof. G. Gutierrez Ospina Assessment Committee Prof. A. Scheurink
Prof. J.C. Billeter Prof. L. Vanderschuren Prof. G. Roldan Roldan
Para mi hermosa, pequeña y amada Agnes For my beloved Agnes Voor mijn kleine lieve Agnes
Contents
Chapter 1 Introduction 9
Chapter 2 Is ejaculation latency related to the size of the genital cortical representation?
35
Chapter 3 Sexual behavior in male Serotonin Transporter Knockout rats 55 Chapter 4 Tramadol: effects on sexual behavior in male rats are mainly
caused by its 5-HT reuptake blocking effects
75
Chapter 5 Tramadol’s inhibitory effects on sexual behavior: pharmacological studies in serotonin transporter knockout rats
97
Chapter 6 Pharmacological studies on the role of 5-HT1A receptors in male sexual behavior of wildtype and serotonin transporter knockout rats
141
Chapter 7 General Discussion 183
Appendix References English Summary Nederlandse samenvatting Resumen en español Acknowledgments Biography List of publications Funding 195 213 223 233 243 249 253 257