University of Groningen
In search of animal models for male sexual dysfunction
Esquivel Franco, Diana
DOI:
10.33612/diss.95008507
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Esquivel Franco, D. (2019). In search of animal models for male sexual dysfunction: Pharmacological
studies in normal and serotonin transporter knockout rats. Rijksuniversiteit Groningen.
https://doi.org/10.33612/diss.95008507
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PROPOSITIONS
1. Even though male sexual dysfunctions are not life threatening, they can generate emotional stressful situations that can significantly affect the individual overall health condition, his interpersonal relationships and the relationship with the partner.
2. Sexual behavior does not only depend on the already known neural structures involved in motivation and implementation, it also depends on neuronal structures that are responsible for the processing of the sensory information. Thus, the anatomical and functional models known are still far from complete.
3. The serotonin transporter knockout (SERT-/-) rat is a good candidate of a
model that resembles sexual dysfunction induced by chronic administration of SSRIs.
4. Even though at the molecular and neurochemical level SERT+/- and SERT -/- are different from animals with full availability of the transporter, there is
no linear relation between the amount of SERT protein available and the level of sexual behavior.
5. The serotonergic system plays a very important role in the regulation of sexual function; thus, chronically administered SSRIs have been shown effective to treat PE. It is however necessary to develop new on-demand treatments to avoid the SSRIs side effects and the need to take SSRIs daily. 6. Chronic administration of SSRIs to treat premature ejaculation can bring
along sexual side effects that cause noncompliance to the treatment. 7. The main effect that tramadol exerts in male sexual function, is related to
the SSRI component in its mechanism of action. However, to get an on-demand effect of tramadol it is necessary to administer a high dose that may come with serious side effects.
8. The stimulation of the 5-HT1A receptor improves sexual activity in male
rats. The use of 5-HT1A receptor (heteroreceptor and autoreceptor) biased
agonists have pro-sexual effects on sexual function, being a good on-demand candidate to treat delayed ejaculation.
9. "Equipped with his five senses, man explores the universe around him and calls the adventure Science." Edwin Powell Hubble
