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University of Groningen

Women’s lifestyle and sexual function

Karsten, Matty

DOI:

10.33612/diss.125792427

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Karsten, M. (2020). Women’s lifestyle and sexual function: the effects of a preconception intervention in women with obesity. University of Groningen. https://doi.org/10.33612/diss.125792427

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WOMEN’S

LIFESTYLE and

SEXUAL FUNCTION

the effects of a preconception

intervention in women with obesity

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C O L O P H O N

Women’s Lifestyle and Sexual Function

the effects of a preconception intervention in women with obesity

PhD thesis, University of Groningen, with a summary in English and a summary in Dutch. Copyright © by M.D.A. (Matty) Karsten

All rights reserved. No part of this (electronic) thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without prior permission of the copyright owner and the publisher holding respective copyrights of the published articles, if applicable. Author: M.D.A. Karsten

Cover design: James Jardine, www.jamesjardine.nl Layout: James Jardine, www.jamesjardine.nl

Photography: Stephan Keereweer, www.stephankeereweer.nl Printing: Ridderprint BV, www.ridderprint.nl

ISBN (printed thesis): 978-94-034-2508-5 ISBN (electronic thesis): 978-94-034-2507-8 The research described in this thesis was supported by:

A grant of the Dutch Heart Foundation (2013T085), a grant from the European Union’s Horizon 2020 research and innovation program DynaHealth (633595) and ZonMw (50-50110-96-518).

Printing of this thesis was supported by:

The Graduate School of Medical Sciences, Research Institute SHARE, University of Groningen, University Medical Center Groningen, the Department of Clinical Epidemiology, Biostatistics and Bioinformatics of the Amsterdam UMC, Amsterdam Reproduction & Development (AR&D) research institute, Chipsoft, Goodlife, Ferring B.V. and Moeders voor Moeders.

Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.

The digital version of this thesis can be found online at: https://www.publicatie-online.nl/publicaties/m-karsten Or by scanning the QR code

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Women’s Lifestyle and Sexual Function

the effects of a preconception intervention in women with obesity

Proefschrift

Ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 10 juni om 16:15 uur

door

Mathilde Danitsja Adaja Karsten

geboren op 18 januari 1989 te Almere

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Promotores Prof. dr. A. Hoek Prof. dr. T.J. Roseboom Copromotor Dr. H. Groen Beoordelingscommissie Prof. dr. P. Enzlin

Prof. dr. E.F.C. van Rossum Prof. dr. ir. D. Kromhout

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Paranimfen Dr. V. Wekker N. Toussaint, PhD

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Chapter 1 General Introduction 11 PART I WOMEN’S LIFESTYLE

Chapter 2 Effects of a preconception lifestyle intervention in obese infertile women on diet and physical activity; a secondary analysis of a randomized controlled trial

PLoS ONE 2018 Nov; 13(11):e0206888

33 Chapter 3 Determinants of successful lifestyle change during a 6-month

preconception lifestyle intervention in women with obesity and infertility

European Journal of Nutrition 2018 Sep; 58(6):2463-2475

57 Chapter 4 Preconception lifestyle intervention reduces long term energy intake

in women with obesity and infertility: a randomised controlled trial

International Journal of Behavioral Nutrition and Physical Activity 2019 Feb; 16(1):3

93 PART II WOMEN’S SEXUAL FUNCTION

Chapter 5 A lifestyle intervention improves sexual function of women with obesity and infertility: a 5 year follow-up of a RCT

PloS ONE 2018 Oct; 13(10):e0205934

119 Chapter 6 The role of PCOS in mental health and sexual function in women

with obesity and a history of infertility

Submitted

141 Chapter 7 Sexual function and pelvic floor activity in women: the role of

traumatic events and PTSD symptoms

Submitted

163 Chapter 8 General Discussion 179

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PART III APPENDICES

English Summary 203 Dutch Summary (Nederlandse Samenvatting) 207 List of Contributing Authors 211 PhD Portfolio 215 List of Publications 219 Research Institute SHARE 221 Acknowledgements (Dankwoord) 225 About the Author (Over de Auteur) 247

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