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Aspirin in the prevention of cardiovascular disease in type 2 diabetes Hovens, M.M.C.

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Citation

Hovens, M. M. C. (2010, June 3). Aspirin in the prevention of cardiovascular disease in type 2 diabetes. Retrieved from https://hdl.handle.net/1887/15583

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/15583

Note: To cite this publication please use the final published version (if applicable).

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ƐƉŝƌŝŶŝŶƚŚĞƉƌĞǀĞŶƟŽŶŽĨĐĂƌĚŝŽǀĂƐĐƵůĂƌĚŝƐĞĂƐĞ ŝŶƉĂƟĞŶƚƐǁŝƚŚƚLJƉĞϮĚŝĂďĞƚĞƐ

DĂƌĐĞů,ŽǀĞŶƐ

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ƐƉŝƌŝŶŝŶƚŚĞƉƌĞǀĞŶƟŽŶŽĨĐĂƌĚŝŽǀĂƐĐƵůĂƌĚŝƐĞĂƐĞ ŝŶƉĂƟĞŶƚƐǁŝƚŚƚLJƉĞϮĚŝĂďĞƚĞƐ

WƌŽĞĨƐĐŚƌŝŌ

dĞƌǀĞƌŬƌŝũŐŝŶŐǀĂŶ

ĚĞŐƌĂĂĚǀĂŶŽĐƚŽƌĂĂŶĚĞhŶŝǀĞƌƐŝƚĞŝƚ>ĞŝĚĞŶ͕

ŽƉŐĞnjĂŐǀĂŶZĞĐƚŽƌDĂŐŶŝĮĐƵƐƉƌŽĨ͘ŵƌ͘W͘&͘ǀĂŶĚĞ,ĞŝũĚĞŶ͕

ǀŽůŐĞŶƐŚĞƚďĞƐůƵŝƚǀĂŶŚĞƚŽůůĞŐĞǀŽŽƌWƌŽŵŽƟĞƐ ƚĞǀĞƌĚĞĚŝŐĞŶŽƉĚŽŶĚĞƌĚĂŐϯũƵŶŝϮϬϭϬ

ŬůŽŬŬĞϭϯ͘ϰϱƵƵƌ

ĚŽŽƌ

DĂƌĐĞůDĂƌŝĂŚƌŝƐƟĂĂŶ,ŽǀĞŶƐ ŐĞďŽƌĞŶŝŶDĂĂƐƚƌŝĐŚƚ

ŝŶϭϵϳϮ

(5)

KǀĞƌŝŐĞůĞĚĞŶ͗ WƌŽĨ͘ƌ͘,͘Wŝũů

 WƌŽĨ͘ƌ͘͘:͘ǀĂŶŽŶŶĞǀĞůĚ

 ƌ͘,͘͘:͘ŝŬĞŶŵ

(6)

ĂŶ:ŽƌŝƐ͕EŝĞůƐĞŶ^ƟũŶ

(7)
(8)

ŽŶƚĞŶƚƐ

ϭ͘ 'ĞŶĞƌĂůŝŶƚƌŽĚƵĐƟŽŶ ϵ

Ϯ͘ WŚĂƌŵĂĐŽůŽŐŝĐĂůƐƚƌĂƚĞŐŝĞƐƚŽƌĞĚƵĐĞĐĂƌĚŝŽǀĂƐĐƵůĂƌƌŝƐŬŝŶ Ϯϯ

 ƚLJƉĞϮĚŝĂďĞƚĞƐ͗ĂŶƵƉĚĂƚĞ

 ƌƵŐƐϮϬϬϱ͖ϲϱ͗ϰϯϯͲϰϰϱ

ϯ͘ īĞĐƚƐŽĨĂƐƉŝƌŝŶŽŶƐĞƌƵŵͲƌĞĂĐƟǀĞƉƌŽƚĞŝŶĂŶĚŝŶƚĞƌůĞƵŬŝŶͲϲ ϰϵ

 ůĞǀĞůƐŝŶƉĂƟĞŶƚƐǁŝƚŚƚLJƉĞϮĚŝĂďĞƚĞƐǁŝƚŚŽƵƚĐĂƌĚŝŽǀĂƐĐƵůĂƌ

 ĚŝƐĞĂƐĞ͗ĂƌĂŶĚŽŵŝnjĞĚƉůĂĐĞďŽͲĐŽŶƚƌŽůůĞĚĐƌŽƐƐŽǀĞƌƚƌŝĂů

 ŝĂďĞƚĞƐKďĞƐDĞƚĂď͘ϮϬϬϴƵŐ͖ϭϬ;ϴͿ͗ϲϲϴͲϳϰ͘

ϰ͘ ,ŝŐŚůĞǀĞůƐŽĨ>>ͲĐŚŽůĞƐƚĞƌŽůĂŶĚƚƌŝŐůLJĐĞƌŝĚĞƐĂŶĚ ϲϱ

 ƉŽŽƌŐůLJĐĞŵŝĐĐŽŶƚƌŽůĂƌĞĂƐƐŽĐŝĂƚĞĚǁŝƚŚĚŝŵŝŶŝƐŚĞĚ

 ĂƐƉŝƌŝŶƌĞƐƉŽŶƐŝǀĞŶĞƐƐŝŶƉĂƟĞŶƚƐǁŝƚŚƚLJƉĞϮĚŝĂďĞƚĞƐ

 :dŚƌŽŵď,ĂĞŵŽƐƚ͘ϮϬϬϳ:Ƶů͖ϱ;ϳͿ͗ϭϱϲϮͲϰ͘

ϱ͘ īĞĐƚƐŽĨĂƐƉŝƌŝŶĐŝƌĐƵůĂƟŶŐϯϰнƐƚĞŵĐĞůůƐĂŶĚϯϰнͬs'&ZϮн ϴϯ

 ĞŶĚŽƚŚĞůŝĂůƉƌŽŐĞŶŝƚŽƌĐĞůůƐŝŶƉĂƟĞŶƚƐǁŝƚŚƚLJƉĞϮĚŝĂďĞƚĞƐ͗

 ĂƌĂŶĚŽŵŝnjĞĚĐƌŽƐƐŽǀĞƌƚƌŝĂů

ϲ͘ WƌĞǀĂůĞŶĐĞŽĨƉĞƌƐŝƐƚĞŶƚƉůĂƚĞůĞƚƌĞĂĐƟǀŝƚLJĚĞƐƉŝƚĞƵƐĞŽĨ ϵϵ

 ĂƐƉŝƌŝŶ͗ĂƐLJƐƚĞŵĂƟĐƌĞǀŝĞǁ͘

 ŵ,ĞĂƌƚ:͘ϮϬϬϳ&Ğď͖ϭϱϯ;ϮͿ͗ϭϳϱͲϴϭ

ϳ͘ >ĂďŽƌĂƚŽƌLJͲĚĞĮŶĞĚĂƐƉŝƌŝŶƌĞƐŝƐƚĂŶĐĞŝƐĂƐƐŽĐŝĂƚĞĚǁŝƚŚĂ ϭϭϳ

 ŚŝŐŚĞƌƌŝƐŬŽĨƌĞĐƵƌƌĞŶƚĐĂƌĚŝŽǀĂƐĐƵůĂƌĞǀĞŶƚƐ͗ĂƐLJƐƚĞŵĂƟĐ

 ƌĞǀŝĞǁĂŶĚŵĞƚĂͲĂŶĂůLJƐŝƐ͘

 ƌĐŚ/ŶƚĞƌŶDĞĚ͘ϮϬϬϳƵŐϭϯͲϮϳ͖ϭϲϳ;ϭϱͿ͗ϭϱϵϯͲϵ͘

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 ƵƌƌŝĐƵůƵŵsŝƚĂĞ ϭϳϳ

 >ŝƐƚŽĨƉƵďůŝĐĂƟŽŶƐ ϭϴϭ

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