• No results found

Molecular dissection of Cdc6 and the miR-148 family : two stories with common themes

N/A
N/A
Protected

Academic year: 2021

Share "Molecular dissection of Cdc6 and the miR-148 family : two stories with common themes"

Copied!
5
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

Molecular dissection of Cdc6 and the miR-148 family : two stories with common themes

Duursma, A.M.

Citation

Duursma, A. M. (2008, May 14). Molecular dissection of Cdc6 and the miR-148 family : two stories with common themes. Retrieved from https://hdl.handle.net/1887/12848

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/12848

Note: To cite this publication please use the final published version (if applicable).

(2)



9B ;9NCB89 79@ <99:H A99F89F9

F9;I@5H=9A97<5B=GA9B8=99FJCCFNCF;9B85H

99B 79@ N=7< CD 99B ;97CBHFC@99F89 A5B=9F

899@H9N9F9;I@5H=9@=;HJ5GH=B897C89J5B

<9H9F:9@=>?A5H9F=55@J5B99B79@<9H(

=>9@?979@89@=B;=G9F99B?@9=B9?5BG85H<9H

(B=9H<9@9A55@;C98;9F9D@=799F8KCF8H

9B?5B9F99BAIH5H=9CBHGH55B15BB99F9F

99BAIH5H=9CBHGH55H=B99BJ5B8979@@I@5=F9

7CBHFC@9A97<5B=GA9B?5B<9H;969IF9B85H

79@@9B N=7< =B <9H @=7<55A CB;97CBHFC@99F8

J9FA9B=;JI@8=;9B15BB99F89N979@@9BN=7<

I=H6F9=89BB55F5B89F9K99:G9@GBC9A9BK9

8=H?5B?9F

)A H9 JCCF?CA9B 85H 9F ( G7<589 9B

8IG?5B?9FCBHGH55H<99:H99B79@A99F89F9

CJ9F@5DD9B89 7CBHFC@9A97<5B=GA9B 8=9

( G7<589 ?IBB9B J5GHGH9@@9B 9B <=9F

J9FJC@;9BG 589EI55H CD F95;9F9B 9N9

F957H=9 KCF8H 89 ( G7<589F9GDCBG9

;9BC9A8 9B 89N9 F9GDCBG9 NCF;H 9FJCCF

85H 99B 79@ CBA=889@@=>? GHCDH A9H 89@9B

9B 69;=BH A9H 89 F9D5F5H=9 J5B <9H (

"=9FB5N5@99B79@K99FJ9F89F89@9BH9BN=>

89G7<589NC55BN=9B@=>?=G85HF9D5F5H=9B=9H

A99F AC;9@=>? =G #B 85H ;9J5@ N5@ 99B 79@

=B D9FA5B9BH9 ;FC9=5FF9GH 6@=>J9B C: 8CC8

;55B

9 ;9B9H=G7<9 7C89 J5B <9H ( KCF8H

=B 99B 79@ J9FH55@8 B55F ,( 85H K99F

J9FH55@8 KCF8H B55F 9=K=HH9B 'IH5H=9G =B

<9H(J5B99B;9B85HJCCF99B69D55@8

9=K=H 7C899FH ?5B 89 :IB7H=9 J5B 85H 9=K=H

J9F5B89F9B A55F ?5B CC? HCH J9F5B89F89

9LDF9GG=989<C9J99@<9=89=K=H8=9J5B,(

9B ( KCF8H ;9A55?H 855FJ5B @9=89B

)C?5B89F9J9F5B89F=B;9B=B99B79@8=9HCH

J9F5B89F89 9=K=H9LDF9GG=9 @9=89B ?IBB9B

99BFC@GD9@9B6=><9HCBHGH55BJ5B?5B?9F

NC5@GJ9F5B89F=B;9B=B69D55@89AC8=75H=9G

J5B <9H ( C: 9=K=HH9B 8=9 55B <9H (

6=B89B 89 NC;9B55A89 9D=;9B9H=G7<9

J9F5B89F=B;9B

,979BH9@=>?N=>B9F?@9=B9,(AC@97I@9BJ5B

  BI7@9CH=89B CBH89?H K55FJ5B ;99B

9=K=H KCF8H ;9A55?H 9N9 AC@97I@9B 89

NC;9B55A89 A=7FC,(G A=,(G 6=B89B

55B;FCH9F9H5F;9H ,(AC@97I@9BK55FJ5B

K9@ 9=K=H KCF8H ;9A55?H "=9F8CCF ?5B

89 J9FH5@=B; J5B ,( B55F 9=K=H KCF89B

;9F9A89B?5B<9HH5F;9H ,(CC?KCF89B

5:;96FC?9B CCF85H A=,(G 89 9LDF9GG=9

J5B ,( B55F 9=K=H F9;I@9F9B ?IBB9B CC?

89N9 ?@9=B9 F9;I@5HCF9B 99B FC@ GD9@9B 6=>

<9HCBHGH55BJ5B?5B?9F

#B <9H 99FGH9 899@ J5B 8=H DFC9:G7<F=:H

"CC:8GHI??9B  9B  KCF8H <9H 9::97H

J5B ( G7<589 CD 89 GH56=@=H9=H J5B

87 99B 69@5B;F=>? ( F9D@=75H=9 9=K=H

69G7<F9J9B "CC:8GHI?  @55H N=9B 85H

G9F=B9:CG:CFM@5H=9J5B878CCF% 

M7@=B9  <9H 87 9=K=H GH56=@=G99FH 9N9

AC8=75H=9 JCCF?CAH <9F?9BB=B; 8CCF 89

 @=;5G9 *8<  8=9 JCCF 89 5:6F55? J5B

87 NCF;H (5 ( G7<589 KCF8H % 

M7@=B9  57H=J=H9=H 97<H9F ;96@C??99F8 CD

99BD 5:<5B?9@=>?9A5B=9FK55F8CCFCC?

87 =BGH56=9@ KCF8H 9B KCF8H 5:;96FC?9B

9 69@5B;F=>?9 FC@ 8=9 87 GD99@H =B 89

=B=H=5H=9 J5B ( F9D@=75H=9 GI;;9F99FH 85H

89 5:6F55? J5B 87 99B FC@ NCI ?IBB9B

GD9@9B =B <9H JCCF?CA9B J5B 79@89@=B; =B

79@@9B A9H ( G7<589 * =G 99B J5B 89

69@5B;F=>?GH9HIACF GIDDF9GGCFG=B99B79@

9BD=G=B<99@J99@HIACF9B;9AIH99F8

9<5@J9 89 D 5:<5B?9@=>?9 F9;I@5H=9 J5B

87B5( G7<589@55H"CC:8GHI?N=9B

85H 8=H F9;I@5H=9A97<5B=GA9 CC? 99B FC@

GD99@HH=>89BGBCFA5@979@89@=B;9@@9BA9H

J9F@55;899LDF9GG=9J5BD;FC9=9BGB9@@9F

99B 9::97H 85H H9B=9H ;9855B ?5B KCF89B

8CCF;9@=>?H=>8=;CC?899LDF9GG=9J5B87

H9J9F@5;9B9N969J=B8=B;9B;9J9BA99F

=BN=7<H =B 89 9GG9BH=O@9 FC@ J5B 87 =B 89

=B=H=5H=9 J5B ( F9D@=75H=9 9B <C9 87

KCF8H ;9F9;I@99F8 =B 89 BCFA5@9 79@7M7@IG

9BB5( G7<589#B"CC:8GHI?KCF89B

89N969J=B8=B;9B9B89=AD@=75H=9G<=9FJ5B

J9F89F698=G7IGG=99F8

#B <9H HK9989 899@ J5B 8=H DFC9:G7<F=:H

"CC:8GHI??9B   9B  KCF8H 89 :IB7H=9

Nederlandse samenvatting

(3)



J5B89A=,  A=,(:5A=@=9CBHF5:9@8

#B "CC:8GHI?  KCF8H 99B B=9IK A=,(

F9;I@5H=9A97<5B=GA9 69G7<F9J9B .CH BI

HC9 K9F8 ;9857<H 85H A=,(G <IB H5F;9H ,(GF9;I@9F9B8CCF55B89U/.,J5B85H

,(H96=B89B<9H;9899@H985HB=9H=B9=K=H

J9FH55@8KCF8H=H<CC:8GHI?@55HN=9B85H=B

<9H;9J5@J5BBAH69BA=,  89N9

F9;I@5H=9D@55HGJ=B8H=B<9H9=K=H7C89F9B89

;9899@H9J5B<9H,(=H<99:H5@G69@5B;F=>?

;9JC@;85H99BBAH6A,(GD@=79 J5F=5BH

8=98=H;9899@H9B=9HHCH9LDF9GG=96F9B;HCC?

B=9H ;9F9;I@99F8 ?5B KCF89B 8CCF 89 A=,   :5A=@=9 )A J9F89F 89 6=C@C;=G7<9

:IB7H=9 J5B 89 A=,   :5A=@=9 H9

?5F5?H9F=G9F9B <9669B K9 89 :IB7H=9 J5B

89N9A=,(GCB89FNC7<H=BJFC9;9<IA5B9

. 79@ CBHK=??9@=B; K=HH9 6@C9879@@9B I=H 89

H<MAIG9B=BDF=A5=F96FC6@5GH9BCA85H

8=H8979@HMD9GN=>BK55F89N9A=,(GA9H

B5A9 HCH 9LDF9GG=9 ?CA9B A=,  6@99?

<CC;HCH9LDF9GG=9H9?CA9B=BAI@H=DCH9BH9

JCCF@CD9F79@@9B 9B =B 5@@9 JFC9;9 . 79@@9B

8=9I=H89N9JCCF@CD9F79@CBHGH55BA=, 

9LDF9GG=9 =G 97<H9F 55BN=9B@=>? J9F@55;8 =B

D@5GA57MHC=89 89B8F=H=G7<9 79@@9B DG

9B B5HIF5@ ?=@@9F 79@@9B 8=9 I=H 8=9N9@:89

AI@H=DCH9BH9 JCCF@CD9F79@@9B CBHGH55B

15BB99F A=,  HCH CJ9F9LDF9GG=9 KCF8H

;96F57<H=BJCCF@CD9F79@@9B8=9J9FJC@;9BG

=B J=HFC B55F DG KCF89B ;98=::9F9BH=99F8

B99AH <9H 55BH5@ DG 8F5A5H=G7< HC9

"CC:8GHI?5B895B89F9?5BHJCB89B

K985H=B<=6=H=9J5BA=, =B6FC6@5GH9B

<9H 8CCF@CD9B J5B 99B 79@89@=B;G7M7@IG

F9A89 "CC:8GHI?  -5A9B GI;;9F9F9B

89N9 85H5 85H 89 A=,   99B FC@ NCI

?IBB9BGD9@9B=B79@89@=B;

#B 8=H DFC9:G7<F=:H ;9H=H9@8 R'C@97I@5=F9

CBHF5:9@=B;J5B879B89A=, :5A=@=9S

?CA9B HK99 J9FG7<=@@9B89 CB89FNC9?G@=>B9B

55B 6C8 #B <9H 99FGH9 ;9899@H9 KCF8H 89

FC@ J5B 99B GD97=9?9 AC8=75H=9 J5B <9H

(F9D@=75H=9 9=K=H87CB89FNC7<HH=>89BG

89 BCFA5@9 79@89@=B;G 7M7@IG 9B B5 (

G7<589 #B <9H HK9989 ;9899@H9 KCF89B 89

:IB7H=9G J5B 99B 69D55@89 A=,( :5A=@=9

89 A=,   :5A=@=9 CBHF5:9@8 (9H 5@G

87GD99@HCC?89N9A=,(:5A=@=9AC;9@=>?

99BFC@=B89F9;I@5H=9J5B79@89@=B;9=89

GHI8=9G;F=>D9B8IG55BCD99BJ5B89A99GH

:5G7=B9F9B89F9;I@5H=9A97<5B=GA9BJ5B99B

79@<9H79@89@=B;G7CBHFC@9A97<5B=GA985H

=B5@@9<IA5B9HIACF9B;989F9;I@99F8=G

(989F@5B8G9-5A9BJ5HH=B;

(4)
(5)

Referenties

GERELATEERDE DOCUMENTEN

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in

Blades and blade fragments seem to have been especially used for longitudinal motions, mainly on plant material (7/12). Flake and flake fragments are used in different motions on

This shape also occurs in the combination artefacts (see below). The shape is the result of intensive use in a repetitive abrasive motion, carried out from different angles. In

Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden.. Note: To cite this publication please use the final

De mogelijkheid van miR-148 om expressie van Dnmt3b splice-varianten te reguleren is een nieuwe variatie op het thema van specifieke genregulatie (dit proefschrift) Net als bij

Since expression of Serpins may facilitate the immune escape of HLA positive tumors, we next analysed the effect of Serpin expression on survival in cases with normal/partial

Detection of amyloid plaques in mouse models of Alzheimer’s disease by magnetic resonance imaging.. Apostolova

miR-152 plays a role in S-phase and G2/M-phase cell cycle progression of diploid fibroblasts B>5' IIFGA5$C57... miR-152 plays a role in S-phase and G2/M-phase cell cycle progression