Molecular dissection of Cdc6 and the miR-148 family : two stories with common themes

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(1)Molecular dissection of Cdc6 and the miR-148 family : two stories with common themes Duursma, A.M.. Citation Duursma, A. M. (2008, May 14). Molecular dissection of Cdc6 and the miR-148 family : two stories with common themes. Retrieved from https://hdl.handle.net/1887/12848 Version:. Corrected Publisher’s Version. License:. Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden. Downloaded from:. https://hdl.handle.net/1887/12848. Note: To cite this publication please use the final published version (if applicable)..

(2) Chapter 7. General Discussion. .

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(4) General Discussion Cancer is a result of multiple genetic and epigenetic alterations, which together change the balance of cellular regulatory mechanisms towards uncontrolled proliferation. Crucial mechanism to prevent cancer are cell cycle checkpoints and the DNA damage response (DDR) that prevents cell cycle progression in the presence of DNA damage or aberrantly replicated DNA. How cells protect themselves from DNA damage and how the cell cycle is regulated are consequently key questions in current cancer research. Furthermore, the role of epigenetic DNA modiﬁcations have received attention for their role in regulating gene expression and genome stability. This thesis describes several aspects of these topics by studying Cdc6 and the miR-148/152 family. In the following section I will discuss the major ﬁndings and their relevance to oncogenesis.. Dual function of Cdc6 in DNA damage checkpoints .<9 FGH GHI8M 89G7F=698 =B H<=G H<9G=G <5DH9F F9J95@G 5 BCJ9@ A97<5B=GA H<5H =G IG98 6M 79@@G HC DF9J9BH ( F9D@=75H=CB=BH<9DF9G9B79C:(85A5;9 19 89ACBGHF5H98 H<5H 87 5B 9GG9BH=5@ DFCH9=B :CF =B=H=5H=CB C: ( F9D@=75H=CB =G 8CKBF9;I@5H98 IDCB =CB=N=B; F58=5H=CB #, =B 5 D 89D9B89BH A5BB9F #B D5FH=7I@5F K9 :CIB8 H<5H G9F=B9 D<CGD<CFM@5H=CB C: 87 6M % M7@=B GH56=@=N9G H<9 DFCH9=B 6M =B<=6=H=B; F97C;B=H=CB 6M H<9 @=;5G9*8< 39H:C@@CK=B;(85A5;9 D=B8I798IDF9;I@5H=CBC:D =B<=6=HGH<=G ?=B5G95B85G5F9GI@H87=G89GH56=@=N98 -=B7987=G9GG9BH=5@:CF=B=H=5H=CBC:( F9D@=75H=CB H<9G9 85H5 GI;;9GH H<5H ( 85A5;9 89D9B89BHF9;I@5H=CBC:87A=;<H D@5M5FC@9=BDF9J9BH=B;(F9D@=75H=CB=B 79@@GK=H<85A5;98( @GC D =B89D9B89BH A97<5B=GA C: 89GHFI7H=CB 5:H9F ( 85A5;9 <5J9 699B 89G7F=698 87 K5G :CIB8 HC 69 89;F5898 :C@@CK=B; HF95HA9BH K=H< H<9 5@?M@5H=B; 5;9BHG 58CN9@9G=B @5B7<5F8 9H 5@

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