University of Groningen
Klotho in vascular biology Mencke, Rik
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Publication date: 2018
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Mencke, R. (2018). Klotho in vascular biology. Rijksuniversiteit Groningen.
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Stellingen behorende bij het proefschrift
Klotho in Vascular Biology
Rik Mencke
1. Klotho protein expression may not be detectable in arteries, but the virtually undetectably low Klotho level does serve physiological functions. (this thesis) 2. The human alternative Klotho mRNA does not serve as the template for a secreted
Klotho protein. (this thesis)
3. Klotho is a quintessential factor in modulating smooth muscle cell differentiation, both directly and indirectly. (this thesis)
4. Studying how the degree of Klotho deficiency in mice correlates with different ageing-related phenotypes may teach us a lot about ageing and Klotho and how the two interrelate. (this thesis)
5. Addressing whether Klotho deserves to be characterised as a bona fide anti-ageing factor requires a more comprehensive biological definition of ageing.
6. The ability to reliably measure serum Klotho levels is a prerequisite for clinical studies on Klotho.
7. There is no great invention, from fire to flying, which has not been hailed as an insult to some god. (J.B.S. Haldane)
8. Facts are meaningless. You could use facts to prove anything that’s even remotely true! (Homer J. Simpson)
9. Nusquam est, qui ubique est. (Seneca) (He who is everywhere, is nowhere.)
10. […] ὅσους βροτέη τέκε γαστήρ, Μοιριδίου κλωστῆρος ἐδουλώθησαν ἀνάγκῃ. (Nonnos of Panoplis)
([…] all mortals born from a womb are by necessity slaves to the spindle of Fate.) 11. क्वचिद् अभद्रात् चिवततते क्वचिद् तद् पुिः िरचत अथो प्रायचित्तम्अपाथतम् मन्ये कुञ्जर-स्हौिवत्
(Śrīmad Bhāgavatam)
(Sometimes one refrains from doing wrong, sometimes one relapses, I therefore
