University of Groningen
The blueprint of microglia
Zhang, Xiaoming
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2018
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Zhang, X. (2018). The blueprint of microglia: Epigenetic regulation of microglia phenotypes. Rijksuniversiteit
Groningen.
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The Blueprint of Microglia
Epigenetic regulation of microglia phenotypes
The Blueprint of Microglia - Epigenetic regulation of microglia phenotypes Xiaoming Zhang
The research presented in this Ph.D. dissertation was conducted at the Section Medical Physiology, Department of Neuroscience, University Medical Center Groningen, University of Groningen, The Netherlands.
The research in this dissertation has been financially supported by the China Scholarship Council (CSC) and stichting Jan Kornelis de Cock.
Printing Ipskamp Printing
Cover design Xiaoming Zhang, the blueprint illustrates how epigenetic regulation specifies microglia responses
Financial support (printing of this thesis)
University Medical Center Groningen University of Groningen
Research School BCN ISBN (printed version) 978-94-034-0678-7 ISBN (electronic version) 978-94-034-0677-0
NUR 881 Medical biology/Medische biologie
Copyright © 2018 by Xiaoming Zhang. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without prior permission of the
The Blueprint of Microglia
Epigenetic regulation of microglia phenotypes
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 30 mei 2018 om 12.45 uur
door
Xiaoming Zhang
geboren op 20 mei 1988
te Henan, China
Promotors
Prof. dr. B.J.L. Eggen
Prof. dr. H.W.G.M. Boddeke
Beoordelingscommissie
Prof. dr. M. Prinz
Prof. dr. U.L.M. Eisel
Prof. dr. J.J. Schuringa
Paranimphs
:Hilmar R. J. van Weering Yang Heng
Table of Contents
Chapter 1 General introduction and outline of the thesis 9
Chapter 2 Long-lasting inflammatory suppression of microglia by
LPS-preconditioning is mediated by RelB-dependent epigenetic silencing
41
Chapter 3 Fungal β-glucan transiently induces trained immunity in
microglia in vivo 89
Chapter 4 Epigenetic regulation of innate immune memory in microglia 123
Chapter 5 Intrinsic DNA damage repair deficiency results in progressive
microglia loss and replacement 163
Chapter 6 Summary and general discussion 203
Chapter 7 Nederlandse samenvatting
Acknowledgements Abbreviations
