University of Groningen
Long-term regulation of microglia Schaafsma, Wandert
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Publication date: 2018
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Schaafsma, W. (2018). Long-term regulation of microglia: Role of epigenetic mechanisms, inflammatory events and diet. Rijksuniversiteit Groningen.
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Long-term regulation of microglia
Role of epigenetic mechanisms, inflammatory events and diet
Research described in this PhD dissertation was conducted at the Section Medical Physiology, Department of Neuroscience, University Medical Centre Groningen, University of Groningen, the Netherlands.
The research in this PhD dissertation was in part funded by the Ministry of Economic Affairs, the Provinces of Drenthe and Groningen, and Friesland Campina and stichting Jan Kornelis de Cock.
Printing of this dissertation was supported by: Universitair medisch centrum Groningen Research School BCN
University of Groningen
Science Impact, Winnipeg, Canada
Print: Ipskamp Printing
ISBN printed version: 978-94-034-0971-9
ISBN electronic version: 978-94-034-0970-2
Copyright © 2018 by Wandert Schaafsma. All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means without prior permission of the author and the publishers holding copyrights of the published articles
Long-term regulation of microglia
Role of epigenetic mechanisms, inflammatory events and diet
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op
woensdag 12 september 2018 om 09.00 uur
door
Wandert Schaafsma
geboren op 23 mei 1984 te Leeuwarden, Nederland
Promotores Prof. dr. B.J.L. Eggen Prof. dr. H.W.G.M. Boddeke Beoordelingscommissie Prof. dr. H.J. Verkade Prof. dr. P.J. Lucassen Prof. dr. I. Bechmann
Contents
Chapter 1………..7 General introduction
Chapter 2………39 Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing
Chapter 3………83 Maternal inflammation induces immune activation of fetal microglia and leads to disrupted microglia immune responses, behavior, and learning performance in adulthood
Chapter 4……….107 Low-fat diet with caloric restriction reduces white matter microglia activation during aging
Chapter 5……….137 An in-vitro model to screen potential anti-inflammatory nutritional compounds for their potential to modulate activation of microglial cells
Chapter 6……….157 General discussion, summary and future perspectives
Chapter 7………..…..169 Nederlandse samenvatting en acknowledgements
