University of Groningen
Long-term regulation of microglia
Schaafsma, Wandert
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Publication date: 2018
Link to publication in University of Groningen/UMCG research database
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Schaafsma, W. (2018). Long-term regulation of microglia: Role of epigenetic mechanisms, inflammatory events and diet. Rijksuniversiteit Groningen.
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Propositions
Accompanying the PhD thesis
Long-term regulation of microglia
Role of epigenetic mechanisms, inflammatory events and diet
1. Lipopolysaccharide (LPS) is able to induce a very long-lasting stable epigenetic reduction of transcription of pro-inflammatory genes in microglia both in vitro and in vivo. (Chapter 2)
2. As observed in macrophages, RelB is a key player in inducing endotoxin tolerance in microglia leading to enrichment of H3K3me2 at promotor regions of pro-inflammatory gene Il-1. (Chapter 2)
3. Prenatal LPS exposure causes fetal microglia activation and thereby long-term and stable changes in gene expression, causing these microglia to react different later in life. (Chapter 3)
4. Prenatal LPS-induced inflammation caused a persistent reduction in BDNF expression, specifically in microglia in the hippocampus. Which can have considerable implications for learning and memory. (Chapter 3)
5. Caloric restriction in LFD mice prevents increased expression of phagocytic markers in white matter microglia with aging, a protective effect of caloric restriction that was not observed in HFD mice.
6. Nutritional intervention with anti-inflammatory nutrients, which are limited in the Western diet, could be important in the prevention and/or treatment of chronic inflammatory states and maintain normal microglia responses. (Chapter 5)
7. Impossible is nothing. (Adidas)
8. The secret of life is to fall seven times and to get up eight times. (Paulo Coelho, The Alchemist)
