Cover Page The handle

Cover Page

The handle http://hdl.handle.net/1887/51101 holds various files of this Leiden University dissertation

Author: Gent, M.D.J.M. van

Title: Tailoring therapy in endometrial and cervical cancer

Issue Date: 2017-06-20

IN ENDOMETRIAL AND CERVICAL CANCER

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IN ENDOMETRIAL AND CERVICAL CANCER

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Mignon Dingena Johanna Maria van Gent

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Journal of gynecol surg, 2012 Oct; volume 28 (issue 6):

398-398

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Int J Gynecol Cancer. 2016 Mar; 26(3):483-90

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Maturitas. 2016 Dec;94.

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Int. J. Gynecol. Cancer. 2017. Accepted

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Int J Gynecol Cancer. 2014 May; 24(4): 735-43

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CHAPTER 1

Introduction

INTRODUCTION – TAILORING THERAPY IN GYNAECOLOGICAL CANCER

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CHAPTER 2

No Surgery for Low-Grade Endometrial Cancer in Women with a desire to Preserve Fertility

Mignon van Gent 0DUMROHLQ.DJLH

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Journal of gynecological surgery 2012 Oct; volume 28 (issue 6): 398-398

CHAPTER 2

No Surgery for Low-Grade Endometrial Cancer in Women with a desire to Preserve Fertility

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ZHUHGHVFULEHG

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SUHVHUYHWKHLUIHUWLOLW\7KHSDWLHQWVKDYHWREHWUHDWHGDFFRUGLQJWRDZHOOGHƓQHGSUH

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2

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2.1 ABSTRACT

Objective

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JRRRSKRUHFWRP\6WDQGDUGWUHDWPHQWWDNHVDZD\WKHSRVVLELOLW\IRUIHUWLOHZRPHQWR

FRQFHLYH 7KLV UHYLHZ VWXGLHV WKH HIIHFWLYHQHVV DQG VDIHW\ RI FRQVHUYDWLYHKRUPRQDO

WKHUDS\IRUVWDJH,JUDGHDQGHQGRPHWULDOFDQFHU

Materials and Methods

:HVHDUFKHG3XEPHGIRUSXEOLFDWLRQVIURP-DQXDU\WR1RYHPEHU3XEOL

FDWLRQVLQFOXGHGUHWURVSHFWLYHVWXGLHVFDVHUHSRUWVPXOWLFHQWHU3KDVH,,VWXG\DQGOLW

HUDWXUHUHYLHZVGHVFULELQJFRQVHUYDWLYHWUHDWPHQWIRUZRPHQZLWKW\SH,HQGRPHWULDO

FDQFHU

Results

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DJHRIWKHSDWLHQWVZDV\HDUV7ZRKXQGUHGDQGWKLUW\WZRSDWLHQWVKDGJUDGHGLV

HDVHDQGKDGJUDGHRUPRUH*UDGLQJZDVXQNQRZQIRUƓYHSDWLHQWV3DWLHQWVZHUH

WUHDWHGZLWKGLIIHUHQWSURJHVWDWLYHV7KUHHRXWRISDWLHQWVGLGQRWUHFHLYHDQ\WUHDW

PHQWIRUWKHLUGLVHDVH7KHPHDQQXPEHURIPRQWKVRIWUHDWPHQWZDVPRQWKV2QH

KXQGUHGDQGQLQHW\WKUHHRIWKHSDWLHQWVUHVSRQGHGLQLWLDOO\WRWKHUDS\3URJHVWHU

RQHUHFHSWRUVWDWXVZDVNQRZQLQRISDWLHQWV6HYHQW\VHYHQSDWLHQWVZHUH

SURJHVWHURQHUHFHSWRUSRVLWLYH7KHPHDQIROORZXSZDVPRQWKV1RSDWLHQWGLHGRI

HQGRPHWULDOFDQFHU2QHKXQGUHGDQGWZHQW\VHYHQSUHJQDQFLHVDQGOLYLQJELUWKV

ZHUHGHVFULEHG

Conclusions

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JURXSRISDWLHQWVVWDJH,JUDGHDQGHQGRPHWULDOFDQFHULQZRPHQZKRZDQWWR

SUHVHUYHWKHLUIHUWLOLW\7KHSDWLHQWVKDYHWREHWUHDWHGDFFRUGLQJWRDZHOOGHƓQHGSUH

VHWSURWRFRO7KHSURFHVVVKRXOGEHZHOOGRFXPHQWHGWRLPSURYHWKHVDIHW\DQGHIIHF

WLYHQHVVRIWKHFRQVHUYDWLYHWUHDWPHQW

2.2 INTRODUCTION

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FOXGLQJELODWHUDOVDOSLQJRRRSKRUHFWRP\+RZHYHUWKLVVWDQGDUGDSSURDFKWDNHVDZD\

WKHSRVVLELOLW\IRUIHUWLOHZRPHQWRFRQFHLYH:HXQGHUWRRNWKLVUHYLHZWRGHWHUPLQH

WKHHIIHFWLYHQHVVDQGVDIHW\RIFRQVHUYDWLYHKRUPRQDOWKHUDS\IRUVWDJH,JUDGHDQG

HQGRPHWULDOFDQFHU

2.3 OBJECTIVES

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FDWHGDVDQDOWHUQDWLYHPHWKRGRIWUHDWPHQWLQH[FHSWLRQDOFDVHVIRU\RXQJZRPHQZKR

ZLVKWRSUHVHUYHWKHLUIHUWLOLW\7KHREMHFWLYHVRIWKLVUHYLHZDUHWRGHWHUPLQHWKH

HIIHFWLYHQHVVDQGVDIHW\RIFRQVHUYDWLYHWKHUDS\IRUVWDJH,JUDGHDQGHQGRPHWULDO

FDQFHUDQGWRIRUPXODWHDSURWRFROWRVDYHIHUWLOLW\LQ\RXQJSDWLHQWVZLWKHQGRPH

WULDOFDQFHU

2.4 MATERIALS AND METHODS

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VXEMHFW7ZRLQYHVWLJDWRUVDEVWUDFWHGWKHGDWD6WXGLHVWKDWZHUHQRWDYDLODEOHRQOLQH

ZHUHKDQGVHDUFKHG

2.5 RESULTS

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VHUYHIHUWLOLW\LVLQFRQFOXVLYHZLWKUHJDUGWRWKHEHVWWUHDWPHQWPRGDOLW\7KHUHDUHPDQ\

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Number of patients

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Grading

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HDVHDQGSDWLHQWVKDGJUDGHRUPRUH*UDGLQJZDVXQNQRZQIRUƓYHSDWLHQWV

Treatment

3DWLHQWV ZHUH WUHDWHG ZLWK PHGUR[\SURJHVWHURQH DFHWDWH 03$ PHJHVWURO DFHWDWH

0$K\GUR[\SURJHVWHURQHFDSURDWH2+SURJQRUHWKLVWHURQHDFHWDWH1$GLK\GUR

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Receptor status

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Follow-up

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OLYLQJELUWKVZHUHGHVFULEHG6L[VWXGLHVGLGQRWPHQWLRQSUHJQDQF\UDWHVDQGWKH

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