University of Groningen
Metabolic capabilities of Lactococcus lactis
Hernandez-Valdes, Jhonatan
DOI:
10.33612/diss.130772158
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Hernandez-Valdes, J. (2020). Metabolic capabilities of Lactococcus lactis: Flavor, amino acids and phenotypic heterogeneity. University of Groningen. https://doi.org/10.33612/diss.130772158
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Flavor, amino acids and phenotypic heterogeneity
Metabolic capabilities
of Lactococcus lactis
The work described in this thesis was performed at the Department of Molecular Genetics, Groningen Institute for Molecular Biology and Bio-technology, Faculty of Science and Engineering, University of Groningen, The Netherlands. The research was supported by the Dutch Technology Foundation stw, which is part of the Netherlands Organization for Scien-tific Research (nwo).
The Graduate School of Science and the University of Groningen finan-cially supported the printing of this thesis.
Printing of this thesis was financially supported by the Netherlands Society of Medical Microbiology (nvmm) and the Royal Netherlands Society for Microbiology (knvm).
Cover design: Emmanuel Páez Pérez. Thesis design: Emmanuel Páez Pérez.
Printed by: Ipskamp Drukkers B.V., Enschede, the Netherlands. ISBN E-book: 978-94-034-2856-7
Metabolic capabilities
of Lactococcus lactis
Flavor, amino acids and phenotypic heterogeneity
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Friday 28 August 2020 at 14.30 hours by
Jhonatan Alejandro Hernandez Valdes
born on 10 December 1990 in Mexico Stad, Mexico
Supervisors
Prof. O.P. Kuipers Prof. J. Kok
Assessment Committee
Prof. A. J. M. Driessen Prof. L. Dijkhuizen Prof. D. van Sinderen
CONTENTS
Chapter 1
General Introduction Part I
Development of bacterial biosensors to detect flavor-promoting compounds
Chapter 2
Development of Lactococcus lactis biosensors for detection of diacetyl
Chapter 3
Draft genome sequences of three amino acid-secreting
Lactococcus lactis strains
Chapter 4
Enhancement of amino acid production and secretion by Lactococcus lactis using a droplet-based biosensing and selection system
Chapter 5
Development of Lactococcus lactis biosensors for detection of sulfur-containing amino acids
Part II
A view of bacteria at the single-cell, single-species culture, and mixed-species level
9 45 47 101 107 153 185
Chapter 6
Another breaker of the wall: The biological Function of the Usp45 protein of Lactococcus lactis
Chapter 7
A riboswitch gives rise to multi-generational phenotypic heterogeneity in an auxotrophic bacterium
Chapter 8
Impact of spatial proximity on territoriality among human skin bacteria
Chapter 9
Summary and General Discussion Nederlandse samenvatting Acknowledgements Publications 187 219 275 311 323 329 333
