University of Groningen
Dyslipidemia in the Young: From Genotype to Treatment Balder, Jan-Willem
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2018
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Balder, J-W. (2018). Dyslipidemia in the Young: From Genotype to Treatment. Rijksuniversiteit Groningen.
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Dyslipidemia in the Young:
From Genotype to Treatment
Jan-Willem Balder
Dyslipidemia in the Young:
From Genotype to Treatment
Jan-Willem Balder
ISBN (printed book): 978-94-034-0491-2 ISBN (Ebook): 978-94-034-0490-5 Design of the cover: Jan-Pieter Balder Printing: Ridderprint, the Netherlands Layout Design: Ridderprint, the Netherlands
The research described in this thesis was supported by a grant of the Dutch Heart Foundation (2015T068).
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Financial support by the Scholten-Cordes Foundation for the publication of this thesis is gratefully acknowledged.
Copyright © 2018 Jan-Willem Balder.
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from the author, or when applicable, from the publishers of the scientific articles.
ISBN (printed book): 978-94-034-0491-2 ISBN (Ebook): 978-94-034-0490-5 Design of the cover: Jan-Pieter Balder Printing: Ridderprint, the Netherlands Layout Design: Ridderprint, the Netherlands
The research described in this thesis was supported by a grant of the Dutch Heart Foundation (2015T068).
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
Financial support by the Scholten-Cordes Foundation for the publication of this thesis is gratefully acknowledged.
Copyright © 2018 Jan-Willem Balder.
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from the author, or when applicable, from the publishers of the scientific articles.
Promotores
Prof. dr. J.A. Kuivenhoven Prof. dr. T.P.W. Kamphuisen Prof. dr. A.J.A. van de Sluis
Beoordelingscommissie Prof. dr. E.S. Stroes Prof. dr. H. Snieder Prof. dr. A.J. Smit
Promotores
Prof. dr. J.A. Kuivenhoven Prof. dr. T.P.W. Kamphuisen Prof. dr. A.J.A. van de Sluis
Beoordelingscommissie Prof. dr. E.S. Stroes Prof. dr. H. Snieder Prof. dr. A.J. Smit
Table of contents
Chapter 1 Introduction
Chapter 2 Adherence to Guidelines to Prevent Cardiovascular Diseases: the Lifelines Cohort Study
Chapter 3 Time to Improve Statin Prescription Guidelines in Low-risk Patients?
Chapter 4 Lipid and Lipoprotein Reference Values From 133,450 Dutch Lifelines Participants: Age- and Gender-specific Baseline Lipid Values and Percentiles
Chapter 5 Pediatric Lipid Reference Values in the General Population:
the Dutch Lifelines Cohort Study
Chapter 6 Non-LDL Dyslipidemia is Prevalent in the Young, and Determined by Lifestyle Factors and Age: the Lifelines Cohort
Chapter 7 Genetics, Lifestyle and LDL-cholesterol in Young and Apparently Healthy Women
Chapter 8 Studying the Role of STAP1 in Cholesterol Metabolism:
Characterization of Stap1 Knockout Mice Chapter 9 General discussion
Addendum Nederlandse samenvatting Dankwoord
Curriculum vitae
References
7
17 33
47
75
93
113
145 169
180 186 188 189
Table of contents
Chapter 1 Introduction
Chapter 2 Adherence to Guidelines to Prevent Cardiovascular Diseases: the Lifelines Cohort Study
Chapter 3 Time to Improve Statin Prescription Guidelines in Low-risk Patients?
Chapter 4 Lipid and Lipoprotein Reference Values From 133,450 Dutch Lifelines Participants: Age- and Gender-specific Baseline Lipid Values and Percentiles
Chapter 5 Pediatric Lipid Reference Values in the General Population:
the Dutch Lifelines Cohort Study
Chapter 6 Non-LDL Dyslipidemia is Prevalent in the Young, and Determined by Lifestyle Factors and Age: the Lifelines Cohort
Chapter 7 Genetics, Lifestyle and LDL-cholesterol in Young and Apparently Healthy Women
Chapter 8 Studying the Role of STAP1 in Cholesterol Metabolism:
Characterization of Stap1 Knockout Mice Chapter 9 General discussion
Addendum Nederlandse samenvatting Dankwoord
Curriculum vitae
References
7
17 33
47
75
93
113
145 169
180 186 188 189