• No results found

University of Groningen

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen"

Copied!
7
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Dyslipidemia in the Young: From Genotype to Treatment Balder, Jan-Willem

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Balder, J-W. (2018). Dyslipidemia in the Young: From Genotype to Treatment. Rijksuniversiteit Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

Download date: 29-06-2021

(2)

Dyslipidemia in the Young:

From Genotype to Treatment

Jan-Willem Balder

Dyslipidemia in the Young:

From Genotype to Treatment

Jan-Willem Balder

(3)

ISBN (printed book): 978-94-034-0491-2 ISBN (Ebook): 978-94-034-0490-5 Design of the cover: Jan-Pieter Balder Printing: Ridderprint, the Netherlands Layout Design: Ridderprint, the Netherlands

The research described in this thesis was supported by a grant of the Dutch Heart Foundation (2015T068).

Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.

Financial support by the Scholten-Cordes Foundation for the publication of this thesis is gratefully acknowledged.

Copyright © 2018 Jan-Willem Balder.

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from the author, or when applicable, from the publishers of the scientific articles.

ISBN (printed book): 978-94-034-0491-2 ISBN (Ebook): 978-94-034-0490-5 Design of the cover: Jan-Pieter Balder Printing: Ridderprint, the Netherlands Layout Design: Ridderprint, the Netherlands

The research described in this thesis was supported by a grant of the Dutch Heart Foundation (2015T068).

Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.

Financial support by the Scholten-Cordes Foundation for the publication of this thesis is gratefully acknowledged.

Copyright © 2018 Jan-Willem Balder.

All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission from the author, or when applicable, from the publishers of the scientific articles.

(4)

(5)

Promotores

Prof. dr. J.A. Kuivenhoven Prof. dr. T.P.W. Kamphuisen Prof. dr. A.J.A. van de Sluis

Beoordelingscommissie Prof. dr. E.S. Stroes Prof. dr. H. Snieder Prof. dr. A.J. Smit

Promotores

Prof. dr. J.A. Kuivenhoven Prof. dr. T.P.W. Kamphuisen Prof. dr. A.J.A. van de Sluis

Beoordelingscommissie Prof. dr. E.S. Stroes Prof. dr. H. Snieder Prof. dr. A.J. Smit

(6)

Table of contents

Chapter 1 Introduction

Chapter 2 Adherence to Guidelines to Prevent Cardiovascular Diseases: the Lifelines Cohort Study

Chapter 3 Time to Improve Statin Prescription Guidelines in Low-risk Patients?

Chapter 4 Lipid and Lipoprotein Reference Values From 133,450 Dutch Lifelines Participants: Age- and Gender-specific Baseline Lipid Values and Percentiles

Chapter 5 Pediatric Lipid Reference Values in the General Population:

the Dutch Lifelines Cohort Study

Chapter 6 Non-LDL Dyslipidemia is Prevalent in the Young, and Determined by Lifestyle Factors and Age: the Lifelines Cohort

Chapter 7 Genetics, Lifestyle and LDL-cholesterol in Young and Apparently Healthy Women

Chapter 8 Studying the Role of STAP1 in Cholesterol Metabolism:

Characterization of Stap1 Knockout Mice Chapter 9 General discussion

Addendum Nederlandse samenvatting Dankwoord

Curriculum vitae

References

7

17 33

47

75

93

113

145 169

180 186 188 189

Table of contents

Chapter 1 Introduction

Chapter 2 Adherence to Guidelines to Prevent Cardiovascular Diseases: the Lifelines Cohort Study

Chapter 3 Time to Improve Statin Prescription Guidelines in Low-risk Patients?

Chapter 4 Lipid and Lipoprotein Reference Values From 133,450 Dutch Lifelines Participants: Age- and Gender-specific Baseline Lipid Values and Percentiles

Chapter 5 Pediatric Lipid Reference Values in the General Population:

the Dutch Lifelines Cohort Study

Chapter 6 Non-LDL Dyslipidemia is Prevalent in the Young, and Determined by Lifestyle Factors and Age: the Lifelines Cohort

Chapter 7 Genetics, Lifestyle and LDL-cholesterol in Young and Apparently Healthy Women

Chapter 8 Studying the Role of STAP1 in Cholesterol Metabolism:

Characterization of Stap1 Knockout Mice Chapter 9 General discussion

Addendum Nederlandse samenvatting Dankwoord

Curriculum vitae

References

7

17 33

47

75

93

113

145 169

180 186 188 189

(7)

Referenties

GERELATEERDE DOCUMENTEN

Here we assessed the bilirubin and lipid phenotype in wild type, heterozygous and homozygous Gunn-Ugt1a1 j/BluHsdRrrc rat littermates in neonatal and adult conditions

increase in fecal UCB and subsequent decrease in plasma UCB levels upon higher intestinal fat concentrations is the result of UCB ‘capturing’ by fatty acids, meaning that

These effects were characterized by increased plasma levels of FGF21, browning of subcutaneous white adipose tissue, increased body temperature and energy expenditure, while

In ApoE-deficient mice, administration of the phenolic acid ferulic acid (FA) increased the hepatic levels of AhR which was associated with a decreased hepatic expression

Bovendien had activering van LXR en FXR geen hypobilirubinemische effecten in Gunn ratten, terwijl LXR activatie zelfs de plasma totale bilirubine (TB) waarden verhoogde,

Disorders of bilirubin and lipid metabolism: models and targets of intervention.. University

The reason for this is that the number of repeated hashes created from the frames are so high using the alternate hashing method, that the number of hash matches go way beyond

Facial expressions checklist Alex Susan Norman Peter William Alex Norman Peter Steve William.. Each table indicates in the first, fourth and a seventh column from